2011 Fiscal Year Final Research Report
Pathogenic role of newly identified regulatory molecule in autoimmune arthritis
| Project/Area Number |
21591261
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | リウマチ学 |
|---|
| Research Abstract |
1)TIARP-/-mice developed spontaneous arthritis, had high serum levels of IL-6, increased CD11b+ cell count in the spleen, and showed enhanced TNF-induced IL-6 expression in macrophages. Sustained degradation of IkBa with dysregulated apoptosis was also noted in TIARP-/-macrophages, and they showed increased IL-6-induced STAT3 phosphorylation. These findings suggested that TIARP is a negative regulator in arthritis by suppressing IL-6 production, its signaling and TNFa-induced NF-kB signaling result in enhanced apoptosis in macrophages. 2)Nine cyclic citrullinated GPI peptides (CCG-1-9) were constructed. Samples were obtained from patients with RA (n=208), healthy subjects (n=174) and other autoimmune diseases (n=202). Anti-CCG-2, 4, 7 Abs were detected in about 30.0% patients with RA, and these Abs were very specific of RA (specificity 99%). Anti-CCG-2, 4, 7 Abs were correlated with anti-CCP, CEP-1 and the presence of HLA-DRB1 SE allele. Treatment with TNF antagonists significantly reduced the levels of anti-CCG-2, 7, suggesting possible diagnostic and activity marker of RA.
|
-
-
[Journal Article] Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population2012
Author(s)
Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, TsuchiyaN.
-
Journal Title
-
[Journal Article] Six-transmembrane epithelialantigen of prostate4(STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis2012
Author(s)
Tanaka Y, *Matsumoto I, Iwanami K, Inoue A, Umeda N, Tanaka Y, Sugihara M, Hayashi T, Ito S, Sumida T
-
Journal Title
Clin. Exp. Rheumatol
Volume: 30
Pages: 99-102
-
-
[Journal Article] Overexpression of T-bet generegulates murine autoimmune arthritis2012
Author(s)
Kondo Y, Iizuka M, Wakamatsu E, Yao Z, Tahara M, Tsuboi H, Sugihara M, Hayashi T, Yoh K, Takahiashi S, Matsumoto I, andSumida T
-
Journal Title
Arthritis Rheum
Volume: 64
Pages: 162-72
-
[Journal Article] Six-transmembraneepithelial antigen of prostate4(STEAP4) is TNFalpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis2012
Author(s)
Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S and Sumida T
-
Journal Title
Mod.Rheumatol
Volume: 22
Pages: 128-36
-
-
[Journal Article] Cumulative Association of Eight Susceptibility Genes with Systemic Lupus Erythematosus in a Japanese Female Population2011
Author(s)
Koga M, Kawasaki A, Ito I, Furuya T, OhashiJ, Kyogoku C, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Hashimoto H, Sumida T and Tsuchiya N
-
Journal Title
J Hum Genet
Volume: 56
Pages: 503-507
-
[Journal Article] Importance of serine 727 phosphorylated STAT1 in IFNgamma-inducedsignaling and apoptpsis of human salivarygland cells2011
Author(s)
Tsuboi H, Wakamatsu E, Iizuka M, Nakamura Y, Sugihara M, Suzuki T, Ogishima H, Hayashi T, Goto D, Ito S, Matsumoto I, Sumida T
-
Journal Title
Int. J. Rheum Dis.
Volume: 14
Pages: 86-91
-
-
[Journal Article] Toll-like receptor 7(TLR7) SNPs in the 3' untranslated region and intron additively contribute to susceptibility to systemic lupus erythematosus in a Japanese female population2011
Author(s)
Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T andTsuchiya N
-
Journal Title
Arthritis Res.
Volume: 13
Pages: 41
-
[Journal Article] Association of afunctional polymorphism in the 3' untranslated region of SPI1 with systemic lupus erythematosus2011
Author(s)
Hikami K, Kawasaki A, Ito I, Koga M, Ito S, Hayashi T, Matsumoto I, Tsutsumi A, KusaoiM, Takasaki Y, Hashimoto H, Arinami T, Sumida T and Tsuchiya N
-
Journal Title
Arthritis Rheum
Volume: 63
Pages: 755-763
-
[Journal Article] Comparative suppressive effect in models of autoimmune arthritis by tyrosine kinase inhibitors imatinib and nilotinib2011
Author(s)
Akashi N, Matsumoto I, Tanaka Y, Inoue A, Yamamoto K, Tanaka Y, Umeda N, Hayashi T, Goto D, Ito S, Sekiguchi K and Sumida T
-
Journal Title
Mod.Rheumatol
Volume: 21
Pages: 267-275
-
[Journal Article] Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis2010
Author(s)
Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Murata H, Tsutsumi A, Hayashi T, Uchida K, Usui J, Yamagata K and Sumida T
-
Journal Title
Clin. Exp. Immunol
Volume: 159
Pages: 1-10
-
[Journal Article] A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models2010
Author(s)
Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M, Li W, Inoue Y, Ackermann K, Shirota H, Matsumoto I, Spyvee M, Schiller S, Sumida T, Gusovsky Fand Lamphier M
-
Journal Title
Br J. Pharmacol
Volume: 160
Pages: 292-310
-
[Journal Article] Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population2010
Author(s)
Ito I, Kawasaki A, Ito S, Kondo Y, Sugihara M, Horikoshi M, Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Takasaki Y, Hashimoto H, Matsuta K, Sumida T and Tsuchiya N
-
Journal Title
Ann Rheum Dis
Volume: 69
Pages: 936-937
-
-
[Journal Article] New low-field extremity MRI, compact Tscan : comparison with whole body1.5 tesla conventional MRI2010
Author(s)
Suzuki T, Ito S, Handa S, Kose K, Okamoto Y, Minami M, Sugihara M, Horikoshi M, TsuboiH, Hayashi T, Goto D, Matsumoto I andSumida T
-
Journal Title
Mod. Rheumatol
Volume: 20
Pages: 331-336
-
-
-
-
[Journal Article] Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis2010
Author(s)
Horikoshi M, Suzuki T, Sugihara M, Kondo Y, Tsuboi H, Uehara T, Hama M, Takase K, OhnoS, Ishigatsubo Y, Yoshida Y, Sagawa A, IkedaK, Ota T, Matsumoto I, Ito S and Sumida T
-
Journal Title
Mod. Rheumatol
Volume: 20
Pages: 556-560
-
-
[Journal Article] Association of TNIP1 with systemic lupus erythematosus in a Japanese population : a case-control association study2010
Author(s)
Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham R R, Matsuta K, Behrens T W, Tohma S, Takasaki Y, Hashimoto H, Sumida T andTsuchiya N
-
Journal Title
Arthritis Res.
Volume: 12
Pages: 174
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 日本臨床免疫学会雑誌2010
Author(s)
坪井洋人, 松尾直美, 飯塚麻菜, 中村友美, 松本功, 住田孝之
Total Pages
222-228
Publisher
シェーグレン症候群におけるM3ムスカリン作動性アセチルコリン受容体抗体のエピトープと機能解析
-
-
-
