2011 Fiscal Year Final Research Report
Development of a new stem cell transplantation regimen in the treatment of refractory autoimmune diseases
Project/Area Number |
21591266
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HORIUCHI TAKAHIKO 九州大学, 医学研究院, 准教授 (90219212)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 造血幹細胞移植 / 自己免疫疾患 / CD34陽性細胞 / 免疫再構築 / 純化 |
Research Abstract |
The objective was to determine the best regimen of autologous hematopoietic stem cell transplantation(auto-HSCT) for refractory autoimmune diseases. CD34+ selected auto-HSCT was more effective on skin sclerosis and more strongly associated with viral infection than unmanipulated auto-HSCT in patients with systemic sclerosis(SSc). The gene expression profile of lymphocytes more normalized in SSc patients who received CD34+ selected auto-HSCT than those who received unmanipulated auto-HSCT. In conclusion, CD34+ selected auto-HSCT should be applied in the treatment of refractory autoimmune diseases.
|
Research Products
(16 results)
-
[Journal Article] CIN8s is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012
Author(s)
Niiro H, JabbarzadehTabrizi S, Kikushige Y, Shima T, Neda K, eta S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, and Akashi K.
-
Journal Title
Blood
Volume: 119
Pages: 2263-2273
Peer Reviewed
-
[Journal Article] Analysis of immune re constitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis2011
Author(s)
Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K.
-
Journal Title
predominant reconstitution of Th1 CD4+ T cells. Rheumatology
Volume: 50
Pages: 944-52
Peer Reviewed
-
[Journal Article] Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosus2011
Author(s)
Furukawa M, Kiyohara C, Tsukamoto H, Mitoma H, Kimoto Y, Uchino A, Nakagawa M, Oryoji K, Shimoda T, Akashi K, Harada M, Horiuchi T.
-
Journal Title
Rheumatol Int
Volume: 31
Pages: 365-76
Peer Reviewed
-
[Journal Article] Hereditary Angioedema in Japan : Genetic Analysis of 13 Unrelated Cases2011
Author(s)
Yamamoto T, Horiuchi T, Miyahara H, Yoshizawa S, Maehara J, Shono E, Takamura K, Machida H, Tsujioka K, Kaneko T, Uemura N, Suzawa K, Inagaki N, Umegaki N, Kasamatsu Y, Hara A, Arinobu Y, Inoue Y, Niiro H, Kashiwagai Y, Harashima SI, Tahira T, Tsukamoto H
-
Journal Title
Am J Med Sci
Volume: 342
Pages: 210-214
Peer Reviewed
-
[Journal Article] Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis2011
Author(s)
Yabuuchi H, Matsuo Y, Tsukamoto H, Sunami S, Kamitani T, Sakai S, Hatakenaka M, Nagafuji K, Horiuchi T, Harada M, Akashi K, Honda H.
-
Journal Title
Eur J Radiol
Volume: 79
Pages: e74-79
Peer Reviewed
-
[Journal Article] Tacrolimus is effective for lupus nephritis patients with persistent proteinuria2010
Author(s)
Uchino A, Tsukamoto H, Nakashima H, Yoshizawa S, Furugo I, Mitoma H, Oryoji K, Shimoda T, Niiro H, Tada Y, Yano T, Nonaka T, Oishi R, Akashi K, Horiuchi T.
-
Journal Title
Clin Exp Rheumatol
Volume: 28
Pages: 6-12
Peer Reviewed
-
[Journal Article] Association of killer cell immunoglobulin-like receptoi 2DL5 with systemic lupus erythematosus and accompanying infections2010
Author(s)
Kimoto Y, Horiuchi T, Tsukamoto H, Kiyohara C, Mitoma H, Uchino A, Furugo I, Yoshizawa S, Ueda A, Harashima S, Sawabe T, Tahira T, Hayashi K, Yoshizawa S, Shimoda T, Akashi K, Harada M.
-
Journal Title
Rheumatology
Volume: 49
Pages: 1346-1353
Peer Reviewed
-
[Journal Article] Infectious complications in patients receiving autologous CD34selected hematopoietic stem cell transplantation for severe autoimmune diseases2009
Author(s)
Kohno K, Nagafuji K, Tsukamoto H, Horiuchi T, Takase K, Aoki K, Henzan H, Kamezaki K, Takenaka K, Miyamoto T, Teshima T, Harada M, Akashi K.
-
Journal Title
Transpl Infect Dis
Volume: 11
Pages: 318-323
Peer Reviewed
-
-
-
-
-
-
-
-
[Book] 補体への招待2011
Author(s)
大井洋之、木下タロウ、松下操、塚本浩堀内孝彦、他
Total Pages
232
Publisher
メジカルレビュー社