• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Development of a new stem cell transplantation regimen in the treatment of refractory autoimmune diseases

Research Project

  • PDF
Project/Area Number 21591266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKyushu University

Principal Investigator

TSUKAMOTO Hiroshi  九州大学, 大学病院, 助教 (70304772)

Co-Investigator(Kenkyū-buntansha) HORIUCHI TAKAHIKO  九州大学, 医学研究院, 准教授 (90219212)
Project Period (FY) 2009 – 2011
Keywords造血幹細胞移植 / 自己免疫疾患 / CD34陽性細胞 / 免疫再構築 / 純化
Research Abstract

The objective was to determine the best regimen of autologous hematopoietic stem cell transplantation(auto-HSCT) for refractory autoimmune diseases. CD34+ selected auto-HSCT was more effective on skin sclerosis and more strongly associated with viral infection than unmanipulated auto-HSCT in patients with systemic sclerosis(SSc). The gene expression profile of lymphocytes more normalized in SSc patients who received CD34+ selected auto-HSCT than those who received unmanipulated auto-HSCT. In conclusion, CD34+ selected auto-HSCT should be applied in the treatment of refractory autoimmune diseases.

  • Research Products

    (16 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results) Book (1 results)

  • [Journal Article] CIN8s is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012

    • Author(s)
      Niiro H, JabbarzadehTabrizi S, Kikushige Y, Shima T, Neda K, eta S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, and Akashi K.
    • Journal Title

      Blood

      Volume: 119 Pages: 2263-2273

    • Peer Reviewed
  • [Journal Article] Analysis of immune re constitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis2011

    • Author(s)
      Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K.
    • Journal Title

      predominant reconstitution of Th1 CD4+ T cells. Rheumatology

      Volume: 50 Pages: 944-52

    • Peer Reviewed
  • [Journal Article] Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosus2011

    • Author(s)
      Furukawa M, Kiyohara C, Tsukamoto H, Mitoma H, Kimoto Y, Uchino A, Nakagawa M, Oryoji K, Shimoda T, Akashi K, Harada M, Horiuchi T.
    • Journal Title

      Rheumatol Int

      Volume: 31 Pages: 365-76

    • Peer Reviewed
  • [Journal Article] Hereditary Angioedema in Japan : Genetic Analysis of 13 Unrelated Cases2011

    • Author(s)
      Yamamoto T, Horiuchi T, Miyahara H, Yoshizawa S, Maehara J, Shono E, Takamura K, Machida H, Tsujioka K, Kaneko T, Uemura N, Suzawa K, Inagaki N, Umegaki N, Kasamatsu Y, Hara A, Arinobu Y, Inoue Y, Niiro H, Kashiwagai Y, Harashima SI, Tahira T, Tsukamoto H
    • Journal Title

      Am J Med Sci

      Volume: 342 Pages: 210-214

    • Peer Reviewed
  • [Journal Article] Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis2011

    • Author(s)
      Yabuuchi H, Matsuo Y, Tsukamoto H, Sunami S, Kamitani T, Sakai S, Hatakenaka M, Nagafuji K, Horiuchi T, Harada M, Akashi K, Honda H.
    • Journal Title

      Eur J Radiol

      Volume: 79 Pages: e74-79

    • Peer Reviewed
  • [Journal Article] Tacrolimus is effective for lupus nephritis patients with persistent proteinuria2010

    • Author(s)
      Uchino A, Tsukamoto H, Nakashima H, Yoshizawa S, Furugo I, Mitoma H, Oryoji K, Shimoda T, Niiro H, Tada Y, Yano T, Nonaka T, Oishi R, Akashi K, Horiuchi T.
    • Journal Title

      Clin Exp Rheumatol

      Volume: 28 Pages: 6-12

    • Peer Reviewed
  • [Journal Article] Association of killer cell immunoglobulin-like receptoi 2DL5 with systemic lupus erythematosus and accompanying infections2010

    • Author(s)
      Kimoto Y, Horiuchi T, Tsukamoto H, Kiyohara C, Mitoma H, Uchino A, Furugo I, Yoshizawa S, Ueda A, Harashima S, Sawabe T, Tahira T, Hayashi K, Yoshizawa S, Shimoda T, Akashi K, Harada M.
    • Journal Title

      Rheumatology

      Volume: 49 Pages: 1346-1353

    • Peer Reviewed
  • [Journal Article] Infectious complications in patients receiving autologous CD34selected hematopoietic stem cell transplantation for severe autoimmune diseases2009

    • Author(s)
      Kohno K, Nagafuji K, Tsukamoto H, Horiuchi T, Takase K, Aoki K, Henzan H, Kamezaki K, Takenaka K, Miyamoto T, Teshima T, Harada M, Akashi K.
    • Journal Title

      Transpl Infect Dis

      Volume: 11 Pages: 318-323

    • Peer Reviewed
  • [Journal Article] Kyushu Sapporo SLE Study Group. Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE : findings from the KYSS study2009

    • Author(s)
      Horiuchi T, Washio M, Kiyohara C, Tsukamoto H, Tada Y, Asami T, Ide S, Kobashi G, Takahashi H
    • Journal Title

      Rheumatology

      Volume: 48 Pages: 1045-1049

    • Peer Reviewed
  • [Presentation] 全身性硬化症に対するCD34陽性細胞純化及び非純化自己造血幹細胞移植2011

    • Author(s)
      塚本浩、堀内孝彦、新納宏昭、他
    • Organizer
      第55回日本リウマチ学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-07-20
  • [Presentation] CD34-selected and unmanipulated autologous hematopoietic stem cell transplantation for severe systemic sclerosis2011

    • Author(s)
      Tsukamoto H, Horiuchi T, Miyamoto T, et al
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      London, UK
    • Year and Date
      2011-05-27
  • [Presentation] Autologous hematopoietic stem cell transplantation for severe systemic sclerosis2010

    • Author(s)
      Tsukamoto H, Horiuchi T, Miyamoto T, et al
    • Organizer
      long-term follow-up analysis of immune reconstitution. Annual European Congress of Rheumatology
    • Place of Presentation
      Rome. Italy
    • Year and Date
      2010-06-18
  • [Presentation] 全身性硬化症に対する大量免疫抑制療法と自己造血幹細胞移植2010

    • Author(s)
      塚本浩、堀内孝彦、三苫弘喜、他
    • Organizer
      第54回日本リウマチ学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-04-24
  • [Presentation] 全身性硬化症に対する大量免疫抑制療法と自己末梢血純化CD34陽性細胞移植:術後5年間の臨床成績と免疫学的検討2009

    • Author(s)
      塚本浩、堀内孝彦、三苫弘喜、他
    • Organizer
      第53回日本リウマチ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
  • [Presentation] 全身性硬化症に対する大量免疫抑制療法と非純化自己末梢血細胞移植の短期成績2009

    • Author(s)
      塚本浩、堀内孝彦、三苫弘喜、他
    • Organizer
      第53回日本リウマチ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
  • [Book] 補体への招待2011

    • Author(s)
      大井洋之、木下タロウ、松下操、塚本浩堀内孝彦、他
    • Total Pages
      232
    • Publisher
      メジカルレビュー社

URL: 

Published: 2013-07-31   Modified: 2017-10-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi