2011 Fiscal Year Final Research Report
c-Cbl-interacting protein of 85 kDa(CIN85) regulates the function of autoreactive B cells
Project/Area Number |
21591267
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 医学研究院, 教授 (80380385)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 自己免疫疾患 / 細胞・組織 / 免疫学 / シグナル伝達 / 内科 |
Research Abstract |
In the present study, we have shown a novel effect of CIN85 on the differentiation of human B cells, and have also established Bcellspecific C1N85 knockdown mice that can serve to evaluate an in vivo function of this adaptor molecule.
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