2013 Fiscal Year Final Research Report
The study of pathogenesis of rapidly progressive interstitial pneumonia associated with polymyositis/dermatomyositis and its novel treatments
| Project/Area Number |
21591269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Keio University |
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Principal Investigator |
KAMEDA Hideto 慶應義塾大学, 医学部, 講師 (00265795)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 間質性肺炎 / 皮膚筋炎 / イマチニブ / 線維芽細胞 |
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| Research Abstract |
Intratracheal injection of bleomycin 2 mg/kg (low dose) and 10 mg/kg (high dose) induced fibrotic lung lesions and hemorrhagic lung lesions, respectively. Thus, mice models of rapidly progressive interstitial pneumonia have been established.
Moreover, a 3-dimensional mixed culture of human lung epithelial cells and human pulmonary fibroblasts was used as a screening test for novel therapeutic agents for rapidly progressive interstitial pneumonia. Imatinib, a drug for chronic myeloid leukemia, selectively inhibited the proliferation of pulmonary fibroblasts stimulated by platelet-derived growth factor.
These results elucidated the possible treatment of rapidly progressive interstitial pneumonia by targeted therapies.
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[Journal Article] Japanese Respiratory Society Committee for formulation of Consensus statement for the diagnosis and treatment of drug-induced lung injuries2013
Author(s)
Kubo A, Azuma A, Kanazawa M, Kameda H, Kusumoto M, Genma A, Saijo Y, Sakai F, Sugiyama Y, Tatsumi K, Dohi M, Tokuda H, Hashimoto S, Hattori N, Hanaoka M, Fukuda Y
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Journal Title
Respir Invest
Volume: 51
Pages: 260-277
Peer Reviewed
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[Presentation] Influence of tocilizumab to interstitial pneumonia (IP) complicating rheumatoid arthritis patients2009
Author(s)
Nishimura K, Kameda H, Kurasawa T, Kondo T, Okuyama A, Nishi E, Takei H, Suzuki K, Nagasawa H, Abe H, Tsuzaka K, Amano K, Takeuchi T
Organizer
The 9th World Congress on Inflammation
Place of Presentation
東京
Year and Date
2009-07-07
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[Presentation] 関節リウマチ合併間質性肺炎患者に対するトシリズマブ投与の影響2009
Author(s)
西村幸治, 亀田秀人, 倉沢隆彦, 近藤恒夫, 奥山あゆみ, 西英子, 武井博文, 鈴木勝也, 長澤逸人, 阿部治男, 津坂憲政, 天野宏一, 竹内勤
Organizer
第53回日本リウマチ学会総会・学術集会
Place of Presentation
東京
Year and Date
2009-04-23
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