Analysis of collagen-induced arthritis and bacterial colitis using Cas-L null mice

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591278
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: IWATA Satoshi 東京大学, 医科学研究所, 特任講師 (00396871)
• Project Period (FY): 2009 – 2011
• Keywords: インテグリン / シトロバクター / 病原性大腸菌 / コラーゲン関節炎

Research Abstract

Crk-associated substrate lymphocyte type(Cas-L) is an integrin signaling adaptor protein composed of multiple domains serving as a substrate for a variety of tyrosine kinases. Cas-L functions in diverse biological processes such as cell attachment, migration and invasion, apoptosis, and cell cycle progression. To elucidate the function of Cas-L in autoimmune diseases and host defence, we employed Cas-L knockout mice. It was shown that these mice relatively resistant to collagen-induced arthritis, on the other hands, they were susceptible to Citrobacter rodentium infection of colon.

Research Products

• [Journal Article] Characterization of cancer stem cell properties of CD24 and CD26-positive human malignant mesothelioma cells (2012)
  • Author(s): Yamazaki, H., Naito, M., Ghani, F. I., Dang, N. H., Iwata, S., and Morimoto, C.
  • Journal Title: Biochem Biophys Res Commun Volume: 419 Pages: 529-536
• [Journal Article] Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia (2011)
  • Author(s): Yamazaki, H., Xu, C. W., Naito, M., Nishida, H., Okamoto, T., Ghani, F. I., Iwata, S., Inukai, T., Sugita, K., and Morimoto, C.
  • Journal Title: Biochem Biophys Res Commun Volume: 409 Pages: 14-21
• [Journal Article] Identification of cancer stem cell markers in human malignant mesothelioma cells (2011)
  • Author(s): Ghani, F. I., Yamazaki, H., Iwata, S., Okamoto, T., Aoe, K., Okabe, K., Mimura, Y., Fujimoto, N., Kishimoto, T., Yamada, T., et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 404 Pages: 735-742
• [Journal Article] Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects (2010)
  • Author(s): Otsuki, N., Dang, N. H., Kumagai, E., Kondo, A., Iwata, S., and Morimoto, C.
  • Journal Title: Journal of ethnopharmacology Volume: 127 Pages: 760-767
• [Journal Article] Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation (2010)
  • Author(s): Arimoto-Miyamoto, K., Kadowaki, N., Kitawaki, T., Iwata, S., Morimoto, C., and Uchiyama, T.
  • Journal Title: Immunology Volume: 130 Pages: 137-149
• [Journal Article] SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration (2009)
  • Author(s): Yo, K., Iwata, S., Hashizume, Y., Kondo, S., Nomura, S., Hosono, O., Kawasaki, H., Tanaka, H., Dang, N. H., and Morimoto, C.
  • Journal Title: Biochem Biophys Res Commun
• [Journal Article] CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells (2009)
  • Author(s): Yamazaki, H., Nishida, H., Iwata, S., Dang, N. H., and Morimoto, C.
  • Journal Title: Biochem Biophys Res Commun.
• [Journal Article] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells (2009)
  • Author(s): Nishida, H., Yamazaki, H., Yamada, T., Iwata, S., Dang, N. H., Inukai, T., Sugita, K., Ikeda, Y., and Morimoto, C.
  • Journal Title: Biochem Biophys Res Commun.
• [Journal Article] The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans (2009)
  • Author(s): Hashimoto-Okada, M., Kitawaki, T., Kadowaki, N., Iwata, S., Morimoto, C., Hori, T., and Uchiyama, T.
  • Journal Title: Int Immunol Volume: 21 Pages: 891-904
• [Journal Article] Histamine H1-receptor antagonists with immunomodulating activities : potential use for modulating T helper type 1(Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases. (2009)
  • Author(s): Okamoto, T., Iwata, S., Ohnuma, K., Dang, N. H., and Morimoto, C.
  • Journal Title: Clin Exp Immunol Volume: 157 Pages: 27-34
• [Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-Induced Arthritis (2011)
  • Author(s): Otsuki, N., Iwata, S., Kumagai, S., Yamada, T., Katayose, T., Kichikawa, Y., Hosono, O., Kawasaki, H., Tanaka, H., Dang, N. H., and Morimoto, C.
  • Organizer: 2011 Annual Scientific Meeting of American College of Rheumatology
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 2011-11-07
• [Presentation] Cas-L/Nedd 9ノックアウトマウスを用いたCitrobacter rodentium感染に対するCrk-associated substrate lymphocyte type(Cas-L)の防御機構について (2010)
  • Author(s): 吉川理子,岩田哲史,片寄智規,永井武,三室仁美,後藤明輝,河崎寛,細野治,田中廣壽,森本幾夫
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2010-11-29
• [Presentation] Cas-L/Nedd9ノックアウトマウスを用いた関節炎の解析 (2010)
  • Author(s): 片寄智規,岩田哲史,村上聡,吉川理子,細野治,河崎寛,金井芳之,田中廣壽,森本幾夫
  • Organizer: 第54回日本リウマチ学会総会・学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-04-23
• [Book] Medical Bio特集がん細胞の生物学 (2011)
  • Author(s): 岩田哲史,森本幾夫
  • Total Pages: 35-39
  • Publisher: オーム社
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/cimmuno/
• [Remarks]
  • URL: http://www.h.ims.u-tokyo.ac.jp/gairai/depts-03.html