2011 Fiscal Year Final Research Report
Effects of oral tolerance in allergen-induced airway responses
| Project/Area Number |
21591281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEHIRO Arihiko 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (20243503)
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| Research Collaborator |
ERWIN W gelfand National Jewish Health, Denver, CO, USA, Department of Pediatrics
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| Project Period (FY) |
2009 – 2011
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| Keywords | 気管支喘息 / 免疫寛容 / 気道過敏性 / 気道炎症 |
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| Research Abstract |
Oral administration of soluble antigen before immunization induces peripheral tolerance and is effective in suppressing animal models of autoimmune diseases. However, few studies have focused on effects on Th-2 type diseases. Mice were sensitized to ovalbumin(OVA) and subsequently challenged with OVA via the airways, eliciting airway hyperresponsiveness(AHR) and airway inflammation. The feeding effects of OVA at different phases of the immune response were evaluated. Mice exposed to both multiple high dose feeding and multiple low dose feeding before sensitization with OVA failed to develop AHR or airway inflammation. High dose feeding of OVA also abrogated AHR and partially suppressed airway inflammation when initiated after sensitization with OVA, but prior to challenge ; low dose feeding partially suppressed AHR but did not affect the development of airway inflammation. High dose but not low dose feeding was effective on AHR when initiated even after challenge with OVA. These data indicate that the dose and phase of the response may be critical in dictating the effect of inducing oral tolerance on allergen-induced AHR and airway inflammation
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[Journal Article] Requirement for CCR5 in the development of allergen-induced airway hyperresponsiveness and inflammation2011
Author(s)
Fuchimoto Y, Kanehiro A, Miyahara N, Koga H, Ikeda G, Waseda K, Tanimoto Y, Ueha S, Kataoka M, Gelfand EW, Tanimoto M
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Journal Title
Am J Respir Cell MolBiol
Volume: 45(6)
Pages: 1248-55
Peer Reviewed
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[Journal Article] Blocking the leukotriene B4 receptor 1 inhibits late phase airway responses in established disease2011
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Fuchimoto Y, Kurimoto E, Tanimoto Y, Kataoka M, Tanimoto M, Gelfand EW
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Journal Title
Am J Respir Cell Mol Biol
Volume: 45
Pages: 851-7
Peer Reviewed
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[Journal Article] Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation2009
Author(s)
Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW
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Journal Title
J Immunol
Volume: 183
Pages: 181-90
Peer Reviewed
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[Journal Article] Leukotriene B4 Release from Mast Cells in IgE-Mediated Airway Hyperresponsiveness and Inflammation2009
Author(s)
Miyahara N, Ohnishi H, Miyahara S, Takeda K, Matsubara S, Matsuda H, Okamoto M, Loader JE, Joetham A, Tanimoto M, Dakhama A, Gelfand EW
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Journal Title
Am J Respir Cell Mol Biol
Volume: 40
Pages: 672-82
Peer Reviewed
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[Presentation] Importance of receptor for advanced glycation end products(RAGE) to the development of elastase-induced pulmonary inflammation and emphysema in mice2011
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Kurimoto E, Fuchimoto E, Taniguchi A, Tanimoto Y, Kataoka M, Gelfand EW, Tanimoto M
Organizer
ATS International Conference
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-18
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[Presentation] アレルギー性気道反応における経口免疫寛容の効果2010
Author(s)
宮原信明, 武田勝行, 宮原聡子, 早稲田公一, 栗本悦子, 池田元洋, 古賀光, 谷口暁彦, 能島大輔, 渊本康子, 谷本安, 金廣有彦, 片岡幹男, Gelfand EW, 谷本光音
Organizer
第60回日本アレルギー学会秋期学術大会
Place of Presentation
東京
Year and Date
2010-11-25
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[Presentation] Blockade of the leukotriene B4 receptor 1 suppresses allergen-induced late phase airway development of AHR and inflammation in established asthma2010
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Fuchimoto Y, Koga H, Kurimoto E, Tanimoto Y, Kataoka M, Yanimoto M, Gelfand EW
Organizer
ATS International Conference
Place of Presentation
New Orleans, USA
Year and Date
2010-04-14
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[Presentation] Effect of cysteiny leukotriene receptor antagonist on airway hyperresponsiveness, airway inhlammation, and the development of emphysematous change in a murine model of COPD combined with bronchial asthma2010
Author(s)
Ikeda G, Kanehiro A, Miyahara N, Koga H, Fuchimoto Y, Waseda K, Kurimoto E, Ono K, Hirano A, Tanimoto Y, Kataoka M, Tanimoto M
Organizer
ATS International Conference
Place of Presentation
New Orleans, USA
Year and Date
2010-04-14
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