• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Analysis of the bioactive molecules that enhance the induction and suppressive properties of human regulatory T cells and application to therapy

Research Project

  • PDF
Project/Area Number 21591282
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionEhime University

Principal Investigator

HASEGAWA Hitoshi  愛媛大学, 大学院・医学系研究科, 准教授 (40164826)

Project Period (FY) 2009 – 2011
KeywordsRegulatory T cells / Foxp3 / lipids / Peroxisome proliferator-activated receptor
Research Abstract

We screened 14 kinds of the molecules that enhanced the induction and suppressive function of human regulatory T cells(Treg) from lipid and nuclear receptor ligand libraries. Of these, PPAR agonists increased suppressive function and expression of Foxp3 in induced Tregs(iTregs). PPAR agonist-treated iTregs increased demethylation level of the Foxp3 promoter region and CNS3. Moreover, TSA and ATRA enhanced iTregs generation synergistically with PPAR agonists. On the other hand, lysophosphatidylcholine(LPC) enhances Foxp3 expression and the suppressive function of nTregs through TGF-beta1 produced by nTregs themselves. These agents increased Treg differentiation and induction and may be benefical for the treatment of human autoimmune diseases.

  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (4 results) Presentation (8 results)

  • [Journal Article] Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-βproduction. Biochem2011

    • Author(s)
      Hasegawa H, Lei J, Matsumoto T, Onishi S, Suemori K, Yasukawa M
    • Journal Title

      Biophys. Res. Commun

      Volume: 415 Pages: 526-531

  • [Journal Article] Peroxisome proliferator-activated receptor alpha and gamma agonists together with TGF-beta convert human CD4+ CD25-T cells into functional Foxp3+ regulatory T cells2010

    • Author(s)
      Lei J., Hasegawa H, Matsumoto T, Yasukawa M
    • Journal Title

      J. Immunol

      Volume: 185 Pages: 7186-7198

  • [Journal Article] Human herpesvirus 6 infection impairs Toll-like receptor signaling2010

    • Author(s)
      Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M
    • Journal Title

      Virol. J

      Volume: 10 Pages: 7 : 91

  • [Journal Article] Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions : association with their severity and diversity in lupus models2010

    • Author(s)
      Nakatani K, Yoshimoto S, Iwano M, Asai O, Samejima K, Sakan H, Terada M, Hasegawa H, Nose M, Saito Y
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299 Pages: F207-216

  • [Presentation] Lysophosphatidylcholine enhances suppressive function of human naturally occurring regulatory T cells through TGF-βproduction2011

    • Author(s)
      Hasegawa H, Lei J, Matsumoto T, Onishi S, Suemori K, Yasukawa M
    • Organizer
      75th Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-11-08
  • [Presentation] Analysis of the bioactive molecules that promote the induction of human tolerogenic dendritic cells2011

    • Author(s)
      Matsumoto T, Hasegawa H, Lei J, Onishi S, Suemori K, Yasukawa M
    • Organizer
      75th Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-11-07
  • [Presentation] ヒト制御性T細胞の誘導におけるPPARアゴニストとTSAまたはATRAの併用による相乗効果2011

    • Author(s)
      長谷川均、金磊、松本卓也、大西佐知子、末盛浩一郎、安川正貴
    • Organizer
      第55回日本リウマチ学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-19
  • [Presentation] ヒト免疫寛容樹状細胞の誘導を促進させる生理活性物質の探索2011

    • Author(s)
      松本卓也、長谷川均、金磊、大西佐知子、末盛浩一郎、安川正貴
    • Organizer
      第55回日本リウマチ学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-18
  • [Presentation] Antagonist of CXCL16 ameliorates the progression of vasculitis in arteritis-prone McH5/lpr mice2011

    • Author(s)
      Hasegawa H, Miyazaki T, Lei J, Matsumoto T, Nose M, Yasukawa M
    • Organizer
      19th International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2011-05-26
  • [Presentation] Peroxisome proliferator-activated receptorαandγagonists together with TGF-βconvert human CD4+ CD25-T cells into functional Foxp3+ regulatory T cells2010

    • Author(s)
      Hasegawa H, Lei J, Matsumoto T, Yasukawa M
    • Organizer
      74^<th> Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-11-09
  • [Presentation] PPARαおよびγアゴニストによるヒト制御性Τ細胞への分化誘導機序2010

    • Author(s)
      金磊、長谷川均、松本卓也、河野政志、安川正貴
    • Organizer
      第54回日本リウマチ学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-04-23
  • [Presentation] PPARαおよびPPARγアゴニストはヒト制御性T細胞への誘導や機能を増強する2009

    • Author(s)
      長谷川均、金磊、河野政志、松本卓也、安川正貴
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi