2011 Fiscal Year Final Research Report
The pathogenesis of bronchial asthma via an anion channel, pendrin
| Project/Area Number |
21591284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUHARA Kenji 佐賀大学, 医学部, 教授 (00270463)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 気管支喘息 / イオンチャンネル / ヒポチオシアン酸 / ペルオキシダーゼ / ペンドリン |
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| Research Abstract |
It is suggested that Pendrin, which is an anion channel induced by IL-13, is important for the pathogenesis of bronchial asthma. In this study, we confirmed the involvement of Pendrin in the pathogenesis of bronchial asthma, and present a novel hypothesis that a thiocyanate ion transported by Pendrin to the airway surface is converted to a hypothiocyanous acid by heme-peroxidase enzymes, and then this acid affects airway epithelial cells and amplifies allergic airway inflammation through the activation of NF-kb and ERK.
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[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
Author(s)
Hidetomo Matsushita, Shoichiro Ohta, Hiroshi Shiraishi, Shoichi Suzuki, Kazuhiko Arima, Shuji Toda, Hiroyuki Tanaka, Hiroichi Nagai, Masao Kimoto, Akira Inokuchi, and Kenji Izuhar,
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Journal Title
Int Immunol
Volume: Vol 22, No.9
Pages: 739-747
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[Journal Article] Distinct structural requirements for interleukin-4(IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness2009
Author(s)
Takachika Ito, Shoichi Suzuki, Sachiko Kanaji, Hiroshi Shiraishi, Shoichiro Ohta, Kazuhiko Arima, Go Tanaka, Taro Tamada, Eijiro Honjo, K Christopher Garcia, Ryota Kuroki, and Kenji Izuhara
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Journal Title
J Biol Chem
Volume: Vol 284, No.36
Pages: 24289-24296
Peer Reviewed
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[Journal Article] The mechanism of mucus production in bronchial asthma2009
Author(s)
K Izuhara, S Ohta, H Shiraishi, S Suzuki, K Taniguchi, S Toda, T Tanabe, M Yasuo, K Kubo, T Hoshino, and H Aizawa
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Journal Title
Curr. Med. Chem
Volume: Vol 16, No.22
Pages: 2867-2875
Peer Reviewed
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[Presentation] Development of combined measurement of squamous cell carcinoma antigens 1 and 2 as a potential companion diagnostic for anti-IL-4/ IL-13 therapies in allergic diseases2011
Author(s)
Shoichiro Ohta, Rumiko Shibata, Yoshifumi Nakao, Yoshinori Azuma, Kazuto Taniguchi, Kazuhiko Arima, Shoichi Suzuki, Hiroshi Shiraishi, Tsuyoshi Iwasaka, and Kenji Izuhara
Organizer
21st International Congress of Clinical Chemistry and Laboratory Medicine
Place of Presentation
Berlin, Germany
Year and Date
20110515-19
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