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2011 Fiscal Year Final Research Report

Development of a rapid and simple diagnostic method for detection of atypical pneumonia pathogen

Research Project

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Project/Area Number 21591304
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionKawasaki Medical School

Principal Investigator

MIYASHITA Naoyuki  川崎医科大学, 医学部, 准教授 (50278917)

Co-Investigator(Kenkyū-buntansha) OUCHI Kazunobu  川崎医科大学, 医学部, 教授 (80351899)
Project Period (FY) 2009 – 2011
Keywords感染症診断学
Research Abstract

We developed a rapid and simple diagnostic method for detection of atypical pathogens, Mycoplasma pneumoniae and Chlamydophila pneumoniae, which is major cause of respiratory tract infections. Immunochromatographic test for the detection of IgM antibodies against atypical pathogens has been developed at present. The test can be performed and evaluated in 10 minutes. Basic and clinical results of this test showed good agreement with other world standard serological tests. In addition, we developed a clinical diagnostic method for suspect atypical pneumonia and confirmed the clinical usefulness.

  • Research Products

    (30 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (10 results) Book (10 results)

  • [Journal Article] Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia2012

    • Author(s)
      Miyashita N, Ouchi K., 他6名
    • Journal Title

      BMC Infect Dis

      Volume: 12 Pages: 126

    • URL

      http://www.biomedcentral.com/bmcinfectdis/content

    • Peer Reviewed
  • [Journal Article] Influence of age in the clinical differentiation of atypical pneumonia in adults2012

    • Author(s)
      Miyashita N, Ouchi K., 他5名
    • Journal Title

      Respirology

      Volume: 17 Pages: 354-362

    • DOI

      DOI:10.1111/j.1440-1843.2012.02188.x.

    • Peer Reviewed
  • [Journal Article] Clinical features and the role of atypical pathogens in nursing and healthcare-associated pneumonia(NHCAP): differences between teaching university hospital and community hospital2012

    • Author(s)
      Miyashita N, Ouchi K., 他7名
    • Journal Title

      Intern Med

      Volume: 51 Pages: 585-594

    • URL

      http://www.naika.or.jp/imonline/index.html

    • Peer Reviewed
  • [Journal Article] Clinical potential of diagnostic methods for the rapid diagnosis of Mycoplasma pneumoniae pneumonia in adults2011

    • Author(s)
      Miyashita N, Ouchi K., 他3名
    • Journal Title

      Eur J Clin Microbiol Infect Dis

      Volume: 30 Pages: 439-446

    • URL

      http://www.springerlink.com/content/0934-9723/

    • Peer Reviewed
  • [Journal Article] Evaluation of serological tests for diagnosis of Bordetella pertussis infection in adolescents and adults2011

    • Author(s)
      Miyashita N, Ouchi K., 他2名
    • Journal Title

      Respirology

      Volume: 16 Pages: 1189-1195

    • DOI

      DOI:10.1111/j.1440-1843.2011.02024.x.

    • Peer Reviewed
  • [Journal Article] Outbreak of pertussis in a university laboratory2011

    • Author(s)
      Miyashita N, Ouchi K., 他7名
    • Journal Title

      Intern Med

      Volume: 50 Pages: 879-885

    • URL

      http://www.naika.or.jp/imonline/index.html

    • Peer Reviewed
  • [Journal Article] Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients with over 18 years2011

    • Author(s)
      Miyashita N, Ouchi K., 他7名
    • Journal Title

      J Infect Chemother

      Volume: 17 Pages: 114-118

    • URL

      http://www.springerlink.com/content/1341-321X

    • Peer Reviewed
  • [Journal Article] Macrolide-resistant Mycoplasma pneumoniae in adults with community-acquired pneumonia2010

    • Author(s)
      Miyashita N, Ouchi K., 他3名
    • Journal Title

      Int J Antimicrob Agent

      Volume: 36 Pages: 384-385

    • URL

      http://www.sciencedirect.com/science/journal/09248579

    • Peer Reviewed
  • [Journal Article] Evaluation of false-positive reaction with ELISA for the detection of Chlamydophila pneumoniae-specific IgM antibody in adults2010

    • Author(s)
      Miyashita N, Ouchi K., 他4名
    • Journal Title

      Jpn J Infect Dis

      Volume: 63 Pages: 150-151

    • URL

      http://www.nih.go.jp/niid/ja/jjid.html

    • Peer Reviewed
  • [Journal Article] Radiographic features of Mycoplasma pneumoniae pneumonia : differential diagnosis and performance timing2009

    • Author(s)
      Miyashita N, Ouchi K., 他6名
    • Journal Title

      BMC Med Imaging

      Volume: 9 Pages: 7

    • URL

      http://www.biomedcentral.com/bmcmedimaging/

    • Peer Reviewed
  • [Presentation] Evaluation of the serological tests for diagnosis of Bordetella pertussis infection in adolescents and adults2011

    • Author(s)
      Miyashita N
    • Organizer
      American Coference of Chest Physician Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2011-10-25
  • [Presentation] Comparison of antibiotic efficacy against pertussis in catarrhal phase and paroxysmal phase2011

    • Author(s)
      Miyashita N
    • Organizer
      American Coference of Chest Physician Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2011-10-25
  • [Presentation] Clinical potential of diagnostic methods for the rapid diagnosis of Mycoplasma pneumoniae pneumonia in adults2011

    • Author(s)
      Miyashita N
    • Organizer
      21^<st> European Congress of Clinical Microbiology and Infectious Diseases/27^<th> International Congress of Chemotherapy
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2011-05-09
  • [Presentation] Macrolide-resistant Mycoplasma pneumoniae in Japan2011

    • Author(s)
      Miyashita N
    • Organizer
      21^<st> European Congress of Clinical Microbiology and Infectious Diseases/27^<th> International Congress of Chemotherapy
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2011-05-09
  • [Presentation] Clinical evaluation of two interferon-gamma release assay(IGRA) tests for immunocmpromised patients2010

    • Author(s)
      Miyashita N
    • Organizer
      20^<th> Annual Congress of the European Respiratory Society
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-09-18
  • [Presentation] Comparative study of therapeutic effects of combined chemotherapy including various doses of clarithromycin for pulmonary Mycobacterium avium complex disease2010

    • Author(s)
      Miyashita N
    • Organizer
      20th Annual Congress of the European Respiratory Society
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-09-18
  • [Presentation] Recent advance in management of Legionella infection2010

    • Author(s)
      Miyashita N
    • Organizer
      1^<st> Legionella Workshop in China
    • Place of Presentation
      Shemyang, China
    • Year and Date
      2010-06-30
  • [Presentation] Genome-wide screening of pathogen effectors in Chlamydophila pneumoniae using a yeast expression system2010

    • Author(s)
      Miyashita N
    • Organizer
      12^<th> International Symposium on Human Chlamydial Infections
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      2010-06-21
  • [Presentation] Radiographic features of Mycoplasma pneumoniae pneumonia : differential diagnosis and performance timing2009

    • Author(s)
      Miyashita N
    • Organizer
      American Coference of Chest Physician Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-31
  • [Presentation] Macrolide-resistant Mycoplasma pneumoniae in patients with community-acquired pneumonia in Japan2009

    • Author(s)
      Miyashita N
    • Organizer
      American Coference of Chest Physician Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-10-31
  • [Book] マイコプラズマ、クラミジア-診断に役立つ学べる感染症2012

    • Author(s)
      宮下修行
    • Total Pages
      17-19
    • Publisher
      診断と治療社
  • [Book] 細菌性、非定型肺炎は鑑別したほうがよいか?呼吸器感染症2011

    • Author(s)
      宮下修行
    • Total Pages
      180-184
    • Publisher
      医薬ジャーナル社
  • [Book] クラミジア・ニューモニエ-病原菌の今日的意味2011

    • Author(s)
      宮下修行
    • Total Pages
      672-689
    • Publisher
      医薬ジャーナル社
  • [Book] クラミジア感染症-感染症専門医テキスト2011

    • Author(s)
      宮下修行
    • Total Pages
      888-896
    • Publisher
      南江堂
  • [Book] クラミジア属感染症の検査-感染症専門医テキスト2011

    • Author(s)
      宮下修行
    • Total Pages
      152-153
    • Publisher
      南江堂
  • [Book] 細菌性肺炎と非定型肺炎の鑑別について-ガイドライン/ガイダンス市中肺炎2010

    • Author(s)
      宮下修行
    • Total Pages
      32-36
    • Publisher
      日本医事新報社
  • [Book] クラミドフィラニューモニエ肺炎-呼吸器疾患最新の治療2010-20122010

    • Author(s)
      宮下修行
    • Total Pages
      238-240
    • Publisher
      南江堂
  • [Book] オウム病、肺炎クラミジア感染症-図説臨床看護医学デジタル版8「感染症」2010

    • Author(s)
      宮下修行
    • Publisher
      エディターシップ
  • [Book] クラミジア・ニューモニエ肺炎-呼吸器感染症のすべて2009

    • Author(s)
      宮下修行
    • Total Pages
      139-145
    • Publisher
      南江堂
  • [Book] 肺炎クラミジア肺炎-New専門医を目指すケース・メソッド・アプローチ112009

    • Author(s)
      宮下修行
    • Total Pages
      74-84
    • Publisher
      日本医事新報社

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Published: 2013-07-31  

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