2011 Fiscal Year Final Research Report
温度感受性に基づく代謝機能回復因子の網羅的探索と新規治療法の開発
| Project/Area Number |
21591318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質代謝異常 / ペルオキシソーム |
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| Research Abstract |
To clarify the molecular mechanism of a temperature-sensitive(TS) phenotype in peroxisomal biogenesis disorders(PBD), we analyzed the change of gene expression in the fibroblasts from PBD patients at 37℃and 30℃, using micro array method. Several hypoxia inducible genes may be possible to associate with TS phenomenon, therefore, we continue further study at a condition of hypoxia. Furthermore, we demonstrated mice fed on high-fat diet(HFD) induced hepatic gene expression of peroxisomal metabolism, which may provide useful fundamental information to understand the role of the peroxisomal function in obesity and lifestyle-related diseases.
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[Journal Article] Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome and rhizomelic chondrodysplasia punctata2012
Author(s)
Noriyuki Kanzawa, Nobuyuki Shimozawa, Ronald J. A. Wanders, Kazutaka Ikeda, Yoshiko Murakami, Hans R. Waterham, Satoru Mukai, Morihisa Fujita, Yusuke Maeda, Ryo Taguchi, Yukio Fujiki, and Taroh Kinoshita
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Journal Title
J Lipid Res
Volume: 53
Pages: 653-63
DOI
Peer Reviewed
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[Journal Article] Clinical biochemical and molecular characterization of peroxisomal diseases in Arabs2011
Author(s)
Shaheen R, Al-Dirbashi OY, Al-Hassnan ZN, Al-Owain M, Makhsheed N, Basheeri F, Seidahmed MZ, Salih MAM, Faqih E, Zaidan H, Al-Sayed M, Rahbeeni Z, Al-Sheddi T, Hashem M, Kurdi W, Shimozawa N, Alkuraya FS
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Journal Title
Clin Genet
Volume: 79
Pages: 60-70
DOI
Peer Reviewed
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[Journal Article] Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy(ALD) based on comprehensive resequencing and association studies with ALD phenotypes2011
Author(s)
Matsukawa T, Asheuer M, Takahashi Y, Goto J, Suzuki Y, Shimozawa N, Takano H, Onodera O, Nishizawa M, Aubourg P, Tsuji S
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Journal Title
Neurogenetics
Volume: 12
Pages: 41-50
DOI
Peer Reviewed
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[Journal Article] Clinical aspects and adrenal functions in eleven Japanese children with X-linked adrenoleukodystrophy2010
Author(s)
Miyoshi Y, Sakai N, Hamada Y, Tachibana M, Hasegawa Y, Kiyohara Y, Yamada H, Murakami M, Kondou H, Kimura-Ohba S, Mine J, Sato T, Kamio N, Ueda H, Suzuki Y, Shiomi M, Ohta H, Shimozawa N, Ozono K
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Journal Title
Endocr J
Volume: 57
Pages: 965-972
DOI
Peer Reviewed
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