2011 Fiscal Year Final Research Report
Role of FGF23 in metabolic bone diseases
| Project/Area Number |
21591319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
OZONO Keiichi 大阪大学, 医学系・研究科, 教授 (20270770)
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| Research Collaborator |
MIURA Kohji 大阪大学, 医学部附属病院 (30625695)
FUJIWARA Makoto 大阪大学, 医学部附属病院 (50625697)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リン / カルシウム / FGF23 / klotho / 骨 / 成長 |
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| Research Abstract |
Serum FGF23 levels were lower than 20 pg/ ml and higher than 40 pg/ ml in 21 patients with vitamin D-deficiency and with hypophosphatemic rickets, respectively.
Umbilical blood FGF23 levels were lower than those in normal adults and pregnant woman. On the other hand, umbilical blood soluble klotho levels were higher than those in normal adults and pregnant woman.
Serum FGF23 levels were high in affected fetus of hyp mice, while serum phosphate levels remained in normal range in affected fetus.
Chondrocyte transduced the signal of FGF23 when FGF23 and soluble klotho were given.
Intravenous administration of bisphosphonate rapidly lowered FGF23 levels in patients with osteogenesis imperfecta.
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[Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood2011
Author(s)
Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K.
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Journal Title
J Clin Endocrinol Metab
Volume: 96(6)
Pages: 943-947
Peer Reviewed
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[Journal Article] A Male Patient with Humoral Hypercalcemia of Malignancy(HHM) with Leukocytosis Caused by Cutaneous Squamous Cell Carcinoma Resulting from Recessive Dystrophic Epidermolysis Bullosa2011
Author(s)
Miura K, Umegaki N, Kitaoka T, Kubota T, Namba N, Etani Y, Hirai H, Kogaki S, Nakajima S, Takahashi Y, Tamai K, Katayama I, Ozono K.
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Journal Title
Clin Pediatr Endocrinol
Volume: 20(3)
Pages: 65-71
Peer Reviewed
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[Journal Article] Kitaoka T, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Hirai H, Yamamoto T, Ozono K.2011
Author(s)
Kitaoka T, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Hirai H, Yamamoto T, Ozono K.
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Journal Title
J Bone Miner Metab
Volume: 29(5)
Pages: 598-605
Peer Reviewed
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