2011 Fiscal Year Final Research Report
Molecular and behavioral analysis of transgenic mice of Angelman syndrome gene, Ube3a
| Project/Area Number |
21591327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagasaki University |
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Principal Investigator |
KISHINO Tatsuya 長崎大学, 先導生命科学研究支援センター, 准教授 (70315232)
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| Project Period (FY) |
2009 – 2011
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| Keywords | UBE3A / アンジェルマン症候群 / トランスジェニックマウス / 神経細胞 |
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| Research Abstract |
To address the role of UBE3A in brain development, we generated transgenic UBE3A mice expressing a full length UBE3A cDNA under control of the rat enolase 2, gamma, neuronal(Eno2) promoter. UBE3A-overexpressing transgenic mice showed normal phenotype. Neurobehavioral phenotypes in anxiety-related behaviors and social interactions of AS model mice were partially rescued by transgene expression in striatum neurons.
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