2011 Fiscal Year Final Research Report
EstablishingstrategytocontrolneonatalseizurefolIowingasphyxia
| Project/Area Number |
21591339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
IWATA Osuke 久留米大学, 医学部, 助教 (30465710)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Sachiko 久留米大学, 医学部, 助教 (40465711)
OKAMURA Hisayoshi 久留米大学, 高次脳疾患研究所, 助教 (00454918)
KANDA Hiroshi 久留米大学, 医学部, 助教 (30341340)
OKADA Junichiro 久留米大学, 医学部, 助教 (60389278)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 低酸素虚血 / γアミノ酪酸 / 新生児脳症 / Bumetanide / 新生児けいれん様発作 / 動物モデル / 神経興奮 |
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| Research Abstract |
Newborn infants are vulnerable for seizures, which are generally resistant to anti-convulsants. In our current project, we developed a large animal model of neonatal seizure by titrating the depth of hypo-ventilation insult. To assess the seizure burden following the recovery from the insult, we developed a handy telemetry video EEG system with off-line amplitude-integrated EEG exchanger software, which enabled us to quantitate the frequency and the duration of seizures. Our model would be relevant to the clinical neonatal seizures following perinatal hypoxia-ischaemia, which could be used to assess the impact of the treatment on histopathological changes in the brain as well as to develop new pharmacological treatments.
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[Journal Article] Determinants of outcomes following acute child encephalopathy and encephalitis : pivotal effect of early and delayed cooling2011
Author(s)
Kawano G, Iwata O, Iwata S, Kawano K, Obu K, Kuki I, Rinka H, Shiomi M, Yamanouchi H, Kakuma T, Takashima S, Matsuishi T.
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Journal Title
Research Network for Acute Encephalopathy in Childhood. Arch Dis Child
Volume: 96(10)
Pages: 936-941
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[Journal Article] Utility of subjective sleep assessment tools for healthy preschool children : a comparative study between sleep logs, questionnaires, and actigraphy2010
Author(s)
Iwasaki M, Iwata S, Iemura A, Yamashita N, Tomino Y, Anme T, Yamagata Z, Iwata O, Matsuishi T.
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Journal Title
J Epidemiol
Volume: 20(2)
Pages: 143-149
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[Presentation] ハイリスク児の成長と脳の微細構造2011
Author(s)
木下正啓, 田中祥一朗, 海野光昭, 才津宏樹, 岡田純一郎, 岩田幸子, 神田洋, 松石豊治郎, 前野泰樹, 岩田欧介
Organizer
第47回日本周産期・新生児医学会総会および学術集会
Place of Presentation
札幌
Year and Date
20110710-12
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