2011 Fiscal Year Final Research Report
Association between oxidative/nitosative stress induced by early nutritional status and adult disease
| Project/Area Number |
21591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yukiyo 産業医科大学, 医学部, 助教 (20279334)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小児 / 栄養 / 肥満 / 生活習慣病 / 脂肪細胞 / 酸化ストレス |
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| Research Abstract |
I have studied by this research grant the association of prenatal adipocytokine levels with the postnatal growth, and the redox status in obese school-aged children. Postnatal development of Nesfatin-1, a new appetite regulator, gene expression has also been studied in rats. Furthermore, the production of NO, MCP-1, etc. have been studied in cultured adipocytes stimulated by TNF-alpha, and the effects of some drugs on these. I have planed further adult-disease model experiments. I have also presented the problems of the evaluation methods for obese children.
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[Presentation] シルバーラッセル症候群患者106例の臨床的・分子遺伝学的解析2010
Author(s)
佐藤智子, 松原圭子, 鏡雅代, 長谷川行洋, 吉橋博史, 小野真, 鎌崎穂高, 小川正道, 沼倉周彦, 土橋一重, 他8名
Organizer
第55回日本人類遺伝学会
Place of Presentation
埼玉
Year and Date
20101027-30
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