2011 Fiscal Year Final Research Report
Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.
| Project/Area Number |
21591355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NAKAMURA Makoto 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (10422685)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Notch1シグナル / 顆粒球分化 / 急性骨髄性白血病 |
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| Research Abstract |
Our data indicate that Notch1 signaling activation suppresses PU. 1 expression and granulocytic differentiation through a pathway involving MAML1, and maintains a part of myeloid progenitor cells at the immature stage. Therefore, it suggests that aberrant Notch1 signaling could support the granulocytic transformation and the maintenance of the malignant phenotype.
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Research Products
(2 results)
