2011 Fiscal Year Final Research Report
Clinical significance of cytotoxic factor-mediated graft-versus-leukemia effect against high-risk childhood leukemia
| Project/Area Number |
21591356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
INUKAI Takeshi 山梨大学, 大学院・医学工学総合研究部, 准教授 (30293450)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAHANE Koshi 山梨大学, 医学部・附属病院, 助教 (90377531)
HIROSE Kinuko 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (70436880)
KURODA Itaru 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (30402051)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 白血病 / 造血幹細胞移植 / 移植片対白血病効果 / TRAIL |
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| Research Abstract |
Graft-versus-leukemia(GVL) effect after allogeneic stem cell transplantation can potentially eradicate residual disease in high risk childhood acute lymphoblastic leukemia patients. TRAIL, which is one of cytotoxic factors expressed on cytotoxic T-cells and natural killer cells, is known to play a role in the GVL effect by inducing apoptotic cell death of leukemia cells through death receptors expression on leukemia cells. In the present study, we demonstrated that oncogenic fusion products derived from chromosomal translocations sensitized leukemia cells to TRAIL-mediated apoptosis by upregulating death receptor expression in t(17 ; 19) and Philadelphia chromosome-positive leukemia.
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