2011 Fiscal Year Final Research Report
Novel treatment of neuroblastoma by live-attenuated poliovirus
| Project/Area Number |
21591359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
TOYODA Hidemi 三重大学, 大学院・医学系研究科, 助教 (60525327)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経芽腫 / ポリオウイルス |
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| Research Abstract |
In a previous study, we demonstrated that neuroblastoma subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of neuroattenuated poliovirus(PV). Our results also suggested that the in vivo destruction of neuroblastoma cells by virotherapy lead to a robust antitumor immune response. In accordance with these findings, we started phase 1 clinical trial, novel treatment of neuroblastoma by live-attenuated poliovirus.
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[Journal Article] Multiple cutaneous squamous cell carcinomas in a patient with IFN-γreceptor 2 deficiency2010
Author(s)
Hidemi Toyoda, Masaru Ido, Kyoichi Nakanishi, Takashi Nakano, Hitoshi Kamiya, Akihiko Matsumine, Atsumasa Uchida, Hitoshi Mizutani, Ludovic de Beaucoudrey, Guillaume Vogt, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Yoshihiro Komada
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Journal Title
Journal of Medical Genetics
Volume: 47
Pages: 631-634
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