2011 Fiscal Year Final Research Report
Research on aging of human hematopoietic stem cells
| Project/Area Number |
21591367
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Yasuhiro 鹿児島大学, 医学部歯学部附属病院, 講師 (30398002)
SHINKODA Yuichi 鹿児島大学, 医学部・歯学部附属病院, 特任助教 (50457652)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIRAO Atsushi 金沢大学, がん研究所, 教授 (90343350)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 造血幹細胞 / 造血幹細胞移植 / CD34陽性細胞 / 加齢 / 老化 / 転写因子 |
|---|
| Research Abstract |
To investigate aging of human hematopoietic stem cells, we evaluated the expression levels The median age of the donors was 21 y(range 0.2-44y). The purity of CD34-positive cells was greater than 90%. Both target genes were quantitatively detected in all samples. There was an inverse correlation between the expression level of ikzf1 and the donor's age(r=-0.358, p=0.032). In contrast, there was no correlation between the expression level of cebpa and the donor's age. From the data, the mRNA level of ikzf1 in purified CD34-positive cells may reflect the age of HSCs in human bone marrow.
|
Research Products
(10 results)
-
-
-
[Journal Article] Randomized Trial to Compare LSA2L2-Type Maintenance Therapy to Daily 6-Mercaptopurine and Weekly Methotrexate With Vincristine and Dexamethasone Pulse for Children With Acute Lymphoblastic Leukemia2010
Author(s)
Yoshihisa Nagatoshi, Akinobu Matsuzaki, Aiko Suminoe, Hiroko Inada, Kouichiro Ueda, Kiyoshi Kawakami, Fumio Yanai, Hideki Nakayama, Hiroshi Moritake, Nobuyoshi Itonaga, Noriko Hotta, Kyoko Fujita, Yasufumi Hidaka, Takeharu Yamanaka, Yoshifumi Kawano, Jun
-
Journal Title
Pediatr Blood Cancer
Volume: 55
Pages: 239-247
DOI
Peer Reviewed
-
-
-
-
-
-
-
