2011 Fiscal Year Final Research Report
The study for the relationship between the quantity of Ascaris antigen in the house dust and asthma symptoms of children living in the rural area of Bangladesh
| Project/Area Number |
21591373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Kasei University |
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Principal Investigator |
IWATA Tsutomu 東京家政大学, 家政学部・児童学科, 教授 (00134578)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZAWA Takuya 国立病院機構相模原病院, 臨床研究センター, 室長 (50297686)
KANO Hirotsugu 帝京大学, 医学部附属溝口病院, 准教授 (60292942)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Haruko 神奈川県立保健福祉大学, 教授
KHAN Md al fazal ICDDR, B(バングラデシュ国際下痢生疾患研究所), Principal Investigator
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小児免疫 / アレルギー / 膠原病学 |
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| Research Abstract |
So-called hygiene hypothesis means that better hygienic environment introduce less allergic diseases. This hypothesis is still controversial especially in the developing country where the ascaris infection is mostly endemic. We had published a paper concerning the epidemiological data which showed the morbidity of wheezing is about 16% in Bangladeshi children. The morbidity of ascaris infestation is over 70% in the rural area in Bangladesh. Our data threw the issue against the hygiene hypothesis. We had also showed that high amount of anti-ascaris IgE antibody significantly correlated to the morbidity of wheezy episodes, diagnosed as the bronchial asthma. We hypothesized there might be ascaris antigen in the house-dust which worked as the inhalant allergen. We surveyed the same field in the rural Bangladesh as the one surveyed in 2001.ISAAC questionnaire was used. Sixty one children out of 142(43%) who were wheezy group in 2001 showed wheezing episode yet after 10 years and 79 out of 97(81%) who were not wheezy showed no wheezing episode. This difference was statistically significant by chi square test(p<0.0001). House dust was collected from the bedding of these two groups. Higher amount of ascaris antigen(5.25μg/g dust, 1.15～ 9.36, 95% CI) was detected in the house dust of the wheezy group than the non-wheezy group(2.54μg/g dust, 1.67～ 3.41, 95% CI), although statistically not significant. The newly developed method for detecting ascaris antigen has some limitation, because something was detected from the dust which was collected from Japanese housing. Our result suggested that there might be cross-reactive materials other than ascaris antigen in those house dust collected from two countries. Further research is needed.
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Research Products
(16 results)
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[Journal Article] Japanese pediatric guidelines for the treatment and management of bronchial asthma 20082010
Author(s)
Naomi Kondo, Toshiyuki Nishimuta, Sankei Nishima, Akihiro Morikawa, Yuko Aihara, Toru Akasaka, Akira Akasawa, Yuichi Adachi, Hirokazu Arakawa, Takao Ikarashi, Toshiichi Ikebe, Toshishige Inoue, Tsutomu Iwata, Atsuo Urisu, Motohiro Ebisawa, Yukihiro Ohya, Kenji Okada, Hiroshi Odajima, Toshio Katsunuma, Makoto Kameda, Kazuyuki Kurihara, Yoichi Kohno, Tatsuo Sakamoto, Naoki Shimojo, Yutaka Suehiro, Kenichi Tokuyama, Mitsuhiko Nambu, Yuhei Hamasaki, Takao Fujisawa, Takehiko Matsui, Tomoyo Matsubara, Mitsufumi, Mayumi, Tokuko Mukoyama, Hirohuki Mochizuki, Koichi Yamaguchi and Shigemi Yoshihara
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Journal Title
Pediatrics International
Volume: 52(2)
Pages: 319-326
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[Journal Article] Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro2009
Author(s)
Fuminori Tanabe, Hirotake Kasai, Limin He, Tomohiro Kin, Takashi Fujimoto, Toshihide Kumamoto, Toshiro Hara, Tsutomu Iwata, Masahiko Ito
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Journal Title
International Immunopharmacology
Volume: 9
Pages: 3663-3670
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