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2011 Fiscal Year Final Research Report

Functional role of BMCC1, a prognostic factor of neuroblastoma, in nervous system and neuroblastoma

Research Project

  • PDF
Project/Area Number 21591376
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionChiba Cancer Center (Research Institute)

Principal Investigator

NAKAMURA Yohko  千葉県がんセンター(研究所), 研究局, 主席研究員 (60260254)

Co-Investigator(Kenkyū-buntansha) TATSUMI Yasutoshi  千葉県がんセンター(研究所), 研究局, 研究員 (00450578)
Co-Investigator(Renkei-kenkyūsha) NAKAGAWARA Akira  千葉県がんセンター(研究所), センター長 (50117181)
Project Period (FY) 2009 – 2011
Keywords神経芽腫 / BMCC1 / 神経細胞の増殖と分化 / 神経細胞死 / TrkA / ノックアウトマウス
Research Abstract

Here, we analyzed the molecular function of BMCC1, a novel gene we had identified, and found that BMCC1 is inactivated by phoshorylation with NGF-activated TrkA. This BMCC1 suppression resulted in the activation of Cdc42, and subsequently it was essential for differentiation of neuronal cells. In combination with our previous finding that BMCC1 promoted the NGF-depletion-induced apoptosis of neuronal cells, the findings from this study might be important for understanding the mechanisms of NGF-regulated neuronal cell fate and spontaneous regression of neuroblastoma. Furthermore, we generated a BMCC1 knockout mouse for the first time in the world. This might become a powerful tool for analyzing in vivo function of BMCC1.

  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash12011

    • Author(s)
      Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A
    • Journal Title

      PLoS One

      Volume: 6(5) Pages: e19297

    • DOI

      DOI:10.1038/onc.2010.383

    • Peer Reviewed
  • [Journal Article] Reevaluation of trkA expression as a biological marker of neuroblastoma by high-sensitivity expression analysis-a study of 106 primary neuroblastomas treated in a single institute2010

    • Author(s)
      Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H
    • Journal Title

      J. Pediatr. Surg

      Volume: 45 Pages: 2293-2298

    • Peer Reviewed
  • [Journal Article] LMO3 interacts with p53 and inhibits its transcriptional activity2010

    • Author(s)
      Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 392 Pages: 252-257

    • Peer Reviewed
  • [Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma2009

    • Author(s)
      Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A
    • Journal Title

      Int. J. Oncol

      Volume: 34 Pages: 931-938

    • DOI

      DOI:10.3892/ijo_00000219

    • Peer Reviewed
  • [Presentation] 前立腺がん細胞においてノンコーディングRNAのDD3はアポトーシス促進因子BMCC1の発現抑制を介して細胞増殖を促進する2011

    • Author(s)
      巽康年、高野良、中村洋子、植田健、中川原章
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
  • [Presentation] I Screening and identification of the novel small chemical compounds targeting TrkB by using IBM-World Community Grid imaging2011

    • Author(s)
      Yohko Nakamura, Akiko Suganami, Yutaka Tamura, Tyuji Hoshino, Mayu Fukuda, Hiroki Nagase, Akira Nakagawara
    • Organizer
      第15回日本がん分子標的治療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-23
  • [Presentation] 新規アポトーシス促進因子BMCC1遺伝子座中にコードされるDD3遺伝子の神経芽腫悪性化における意義2010

    • Author(s)
      巽康年、横山智彰、高野良、大平美紀、中川原章
    • Organizer
      第26回日本小児がん学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-18
  • [Presentation] 前立腺がんにおいてlarge non-coding RNAのDD3はBMCC1の発現を抑制し細胞の生存を促進する2010

    • Author(s)
      巽康年、横山智彰、高野良、大平美紀、中村洋子、植田健、中川原章
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
  • [Presentation] DD3, a large non-coding RNA against the pro-apoptotic BMCC1 gene, is a candidate target for treating neuroblastoma2010

    • Author(s)
      巽康年、横山智彰、ウーミャットリン、高野良、高木大輔、大平美紀、中川原章
    • Organizer
      Advanced in Neuroblastoma Research 2010
    • Place of Presentation
      スウェーデン・ストックホルム
    • Year and Date
      2010-06-22
  • [Presentation] 前立腺がんにおけるDD3による新規がん抑制候補遺伝子BMCC1の制御機構2009

    • Author(s)
      巽康年、横山智彰、高野良、植田健、丸岡正幸、伊丹真紀子、好田忠行、大平美紀、中川原章
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01

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Published: 2013-07-31   Modified: 2014-12-04  

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