2011 Fiscal Year Final Research Report
Functional role of BMCC1, a prognostic factor of neuroblastoma, in nervous system and neuroblastoma
| Project/Area Number |
21591376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
NAKAMURA Yohko 千葉県がんセンター(研究所), 研究局, 主席研究員 (60260254)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Yasutoshi 千葉県がんセンター(研究所), 研究局, 研究員 (00450578)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWARA Akira 千葉県がんセンター(研究所), センター長 (50117181)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経芽腫 / BMCC1 / 神経細胞の増殖と分化 / 神経細胞死 / TrkA / ノックアウトマウス |
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| Research Abstract |
Here, we analyzed the molecular function of BMCC1, a novel gene we had identified, and found that BMCC1 is inactivated by phoshorylation with NGF-activated TrkA. This BMCC1 suppression resulted in the activation of Cdc42, and subsequently it was essential for differentiation of neuronal cells. In combination with our previous finding that BMCC1 promoted the NGF-depletion-induced apoptosis of neuronal cells, the findings from this study might be important for understanding the mechanisms of NGF-regulated neuronal cell fate and spontaneous regression of neuroblastoma. Furthermore, we generated a BMCC1 knockout mouse for the first time in the world. This might become a powerful tool for analyzing in vivo function of BMCC1.
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[Journal Article] Reevaluation of trkA expression as a biological marker of neuroblastoma by high-sensitivity expression analysis-a study of 106 primary neuroblastomas treated in a single institute2010
Author(s)
Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H
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Journal Title
J. Pediatr. Surg
Volume: 45
Pages: 2293-2298
Peer Reviewed
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[Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma2009
Author(s)
Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A
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Journal Title
Int. J. Oncol
Volume: 34
Pages: 931-938
DOI
Peer Reviewed
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