2011 Fiscal Year Final Research Report

A study of avidity of Haemophilus influenzae type b (Hib)antibody and multiple copies of capsulation loci in the strains as possible factors of Hib vaccine failure in Japan.

Research Project

Project/Area Number	21591390
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	Tohoku University (2010-2011) Kagoshima University (2009)
Principal Investigator	TOKUDA Koichi 東北大学, 病院, 講師 (10518400)
Co-Investigator(Kenkyū-buntansha)	NISHI Junichiro 鹿児島大学, 医学部・歯学部付属病院, 講師 (40295241)
Project Period (FY)	2009 – 2011
Keywords	ヒブワクチン / vaccine failure / Hib莢膜遺伝子capb領域の重複 / Hib抗体のavidity低下
Research Abstract	Haemophilus influenzae type b (Hib)occasionally causes invasive bacterial diseases such as meningitis especially among young children. In recent years, vaccine failure associated with multiple amplification of the capsulation(capb)locus has been increasingly reported in Europe. We examined Hib strains from Japanese children with Hib meningitis and founded that the proportion of strains with three or four copies of the capb locus already exist before the popularization of Hib vaccination.