2011 Fiscal Year Final Research Report
Elucidation of mediators which exert anti-respiratory syncytial virus activity reacted by double-stranded RNA
| Project/Area Number |
21591391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Hiroyuki 札幌医科大学, 医学部, 教授 (80217348)
OIKAWA Takumi 札幌医科大学, 医学部, 研究員 (70574739)
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| Project Period (FY) |
2009 – 2011
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| Keywords | RSウイルス / 2本鎖RNA / TLR3 / 自然免疫 / 抗ウイルス作用 / インターフェロン |
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| Research Abstract |
To investigate antiviral role of double-stranded(ds) RNA, Toll-like receptor 3(TLR3) whose ligand is dsRNA was overexpressed in A549 cells and those cells were infected with human respiratory syncytial virus(RSV). The TLR3-overexpressed cells produced significantly less amount of RSV in a cell culture supernatant comparing to the control cells. Further investigation suggested that interferon-. was less involved in this effect.
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