2011 Fiscal Year Final Research Report
Genetic variability of human cytomegalovirus UL97 gene which associated with resistance to ganciclovir
| Project/Area Number |
21591392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOTO Yuko 札幌医科大学, 医学部, 講師 (10404659)
HORI Tsukasa 札幌医科大学, 医学部, 助教 (20398324)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヒトサイトメガロウイルス / UL97遺伝子 / ガンシクロビル |
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| Research Abstract |
UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605(D to E) was frequently identified(56/61 : 91. 8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.
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