2011 Fiscal Year Final Research Report
Effects of carnitine to oxygen stress occurred in the reperfused myocardiumfrom the cyanotic congenital heart disease model
| Project/Area Number |
21591395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ITOI Toshiyuki 京都府立医科大学, 医学研究科, 准教授 (10264780)
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| Co-Investigator(Kenkyū-buntansha) |
TOIYAMA Kentarou 京都府立医科大学, 医学研究科, 助教 (00433285)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 未熟心 / 循環器 / 心筋代謝 / 再灌流障害 / 脂質 |
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| Research Abstract |
We have created a rat model of cyanotic congenital heart disease by chronic hypoxic exposure. A constant Langendorff coronary perfusion system was adopted as a new model for examination of cardiac ischemic reperfusion injury. The result was that, contrary to expectations, the hearts from low oxygen exposed rats showed less suppression of cardiac function after ischemic reperfusion to the contrast with the control hearts. Currently, we are considering the sequential changes in the composition of membrane lipids, changes in lipid peroxide production, and changes in the concentration of antioxidant enzymes.
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