2011 Fiscal Year Final Research Report
The effect of fetal cerebral white matter injury on the development of oligodendroglial linages in chronically instrumented premature fetal sheep
| Project/Area Number |
21591407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Hidenobu 東北大学, 病院, 非常勤講師 (80422103)
MIURA Tuichiro 東北大学, 病院, 特任助手 (20419229)
KITANISHI Ryuta 東北大学, 病院, 非常勤講師 (20436116)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 子宮内炎症 / 脳血流量 / 脳虚血 / 胎児 / brain-sparing effect / 脳室周囲白質軟化 / 脳白質損傷 / ヒツジ |
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| Research Abstract |
To determine the effect of cerebral ischemia and/or intrauterine inflammation on the development of oligodendroglial lineage in cerebral white matter, chronically instrumented fetal sheep was induced hemorrhagic hypotensionand/ornecrotizing funifitis. The brain was performed immunohistochemistry of NG2, O4, CNPase and PLP and then integrated density of each stain was statistically compared. The results suggested that in the premature fetal sheep, cerebral ischemia and/or intrauterine inflammation accelerated the oligodendroglial maturity from precursor to post-mitotic cells rather than induced apoptosis to precursor cells in the cerebral white matter.
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