2011 Fiscal Year Final Research Report
Sphingolipid Metabolism in Pregnancy and Fetal Development
| Project/Area Number |
21591414
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kyoto University (2011)
Musashino University (2009-2010) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 胎児医学 / スフィンゴ脂質 |
|---|
| Research Abstract |
Sphingolipid metabolism is critical for the maintenance of normal pregnancy. Disturbance in sphingolipid metabolism causes early pregnancy loss. In this study, I elucidated the mechanism of pregnancy loss using sphingosine kinase-deficient female mice. The CXCL1 levels were markedly increased in the Sphk1^<-/->Sphk2^<+/-> decidua, where considerable amounts of neutrophils infiltrated, leading to embryonic death. These results suggest that sphingosine kinases might play a central role in conferring immune tolerance on the semiallogeneic embryo-fetal transplant by suppressing excessive inflammation in normal pregnancy.
|
-
[Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.2010
Author(s)
Takuwa Noriko, Ohkura Sei-ichiro, Takashima Shin-ichiro, Ohtani Keisuke, Okamoto Yasuo, Tanaka Tamotsu, Hirano Kaoru, Usui Soichiro, Wang Fei, Du Wa, Yoshioka Kazuaki, Banno Yoshiko, Sasaki Motoko, Ichi Ikuyo, Okamura Miwa, Sugimoto Naotoshi, Mizugishi Kiyomi, Nakanuma Yasuni, Ishii Isao, Takamura Masayuki, Kaneko Shuichi, Kojo Shosuke, Satouchi Kiyoshi, Mitumori K unitoshi, Chun Jerold, Takuwa Yoh.
-
Journal Title
Cardiovascular Research
Volume: 85
Pages: 484-493
DOI
Peer Reviewed
-
