Roles for components of the feto-amniotic unit in maintaining pregnancy

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tokai University
• Principal Investigator: ISHIMOTO Hitoshi 東海大学, 医学部, 教授 (10212937)
• Co-Investigator(Kenkyū-buntansha): KONDO Akane 東海大学, 医学部, 講師 (00384884)
• Research Collaborator: JAFFE Robert b. カリフォルニア大学サンフランシスコ校, 医学部, 教授 ; MUENCH Marcus O. カリフォルニア大学サンフランシスコ校, 医学部, 客員准教授
• Project Period (FY): 2009 – 2011
• Keywords: 羊膜 / 胎児 / 副腎 / 羊水 / コルチゾール

Research Abstract

Our results demonstrate that factors that mediate the steroid-producing machinery in the outer zone of the human fetal adrenal gland(HFA), show zonal and/or ontogenic expression patterns relevant to the in vivo occurrence of cortisol and aldosterone synthesis at the periphery of the HFA in late gestation. Results also show that midkine, a heparin-binding growth factor, is likely secreted from the fetal lung into the amniotic fluid, and can suppress amniotic production of prostaglandin E2via COX2down-regulation, indicative of its role as a fetal signal for maintaining pregnancy.

Research Products

• [Journal Article] Development and Function of the Human Fetal Adrenal Cortex : a Key Component in the Feto-Placental Unit (2011)
  • Author(s): Ishimoto H, Jaffe RB
  • Journal Title: Endocrine Reviews Volume: 32(3) Pages: 317-355
  • Peer Reviewed
• [Journal Article] Iwata S 2011Laparoscopic cystectomy of ovarian teratoma in anti-NMDAR encephalitis : two case reports (2011)
  • Author(s): Asai S, Ishimoto H, Yabuno A, Asada H, Seki M
  • Journal Title: J Minim Invasive Gynecol Volume: 18(1) Pages: 135-137
  • Peer Reviewed
• [Journal Article] Expression of ovary-specific acidic protein in steroidogenic tissues : a possible role in steroidogenesis (2009)
  • Author(s): Matsumoto T, Minegishi K, Ishimoto H, Tanaka M, Hennebold JD, Teranishi T, Hattori Y, Furuya M, Higuchi T, Asai S, Kim SH, Miyakoshi K, Yoshimura Y
  • Journal Title: Endocrinology Volume: 150(7) Pages: 3353-3359
  • Peer Reviewed
• [Presentation] Ontogenic Expression of Angiotensin-Converting Enzyme in the Human Fetal Adrenal Gland : Implication in Angiotensin II-Mediated Aldosterone Synthesis (2011)
  • Author(s): Doguchi K, Ishimoto H, Matsumoto T, Kondo A, Sato S, Miyazawa M, Minegishi K, Izumi S, Mikami M, Jaffe RB
  • Organizer: 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston(The Boston Convention & Exhibition Center), USA
  • Year and Date: 2011-06-04
• [Presentation] Midkineのヒト胎児副腎皮質における役割:初代培養細胞とモデル細胞株の比較検討 (2011)
  • Author(s): 道口健翔、石本人士、宮澤昌樹、和泉俊一郎、Jaffe RB
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸(神戸国際展示場)
  • Year and Date: 2011-04-22
• [Presentation] The Human Fetal Adrenal Gland : A Key Component of the Feto-Maternal Unit (2010)
  • Author(s): Ishimoto H
  • Organizer: 第23回韓国周産期学会(The Korean Perinatal Society)
  • Place of Presentation: ソウル(Asan Medical Center)、韓国
  • Year and Date: 2010-11-20
• [Presentation] Invitation to Fetal Endocrinology : Signals from the Fetus (2010)
  • Author(s): Ishimoto H
  • Organizer: 第23回韓国周産期学会(The Korean Perinatal Society)
  • Place of Presentation: ソウル(Samsung Medical Center)、韓国
  • Year and Date: 2010-11-19
• [Presentation] Abundant Expression of Ovary. Specific Acidic Protein in the Midgestation Human Fetal Adrenal Gland : Implications for Fetal Adrenal Androgen Biosynthesis (2010)
  • Author(s): Ishimoto H, Minegishi K, Matsumoto T, Kondo A, Doguchi K, Miyazawa M, Tanaka M, Jaffe RB
  • Organizer: 92th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Diego(The San Diego Convention Center), USA
  • Year and Date: 2010-06-20