2011 Fiscal Year Final Research Report
Impact of magnesium on epigenetics
| Project/Area Number |
21591424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TAKAYA Junji 関西医科大学, 医学部, 講師 (80247923)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胎児医学 |
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| Research Abstract |
Prenatal under-nutrition involves changes in the epigenetic regulation of specific genes. We investigated the effects of feeding pregnant rats a magnesium(Mg)-deficient diet on the methylation of cytosine-guanine(CpG) dinucleotides in hepatic glucocorticoid genes of neonatal offspring, compared with the controls. Mean methylation of the 11ss-hydroxysteroid dehydrogenase-2(Hsd11b2) promoter in the Mg-deficient offspring was higher than in controls. Ppara and Nr3c1 methylation status and expression did not differ between the groups. Therefore, a Mg-deficient diet alters glucocorticoid metabolism, predicting higher hepatic intracellular glucocorticoid concentrations, and is possibly a key mechanism that induces the metabolic complications of Mg deficiency.
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