2011 Fiscal Year Final Research Report
Study on mechanism of dermatitis due to epidermal barrier disruption : analysis of model mouse with epidermis devoid of ceramide
| Project/Area Number |
21591436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kochi University |
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Principal Investigator |
SANO Shigetoshi 高知大学, 教育研究部・医療学系, 教授 (80273621)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Kimiko 高知大学, 教育研究部・医療学系, 講師 (20403892)
YAMAMOTO Mayuko 高知大学, 教育研究部・医療学系, 助教 (20423478)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 皮膚病理学 |
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| Research Abstract |
Here, we generated Sptlc2 targeted mice under control of the keratin 5 promoter(referred to as K5-SPT-KO mice), by which their keratinocytes were devoid of SPT. These mice demonstrated lower water-holding capacity and barrier dysfunction. From 2 weeks of age, they developed skin inflammation, showing psoriasis-like histopathologic changes. K5-SPT-KO mice showed increased numbers ofγδ-T cells that produced IL-17(γδ-17) in the skin lesion and lymph nodes and most of them also produced IL-22, similar to Th17 cells. In vivo administration of anti-IL-12/ 23p40 antibody ameliorated the skin lesions and reducedγδ-17 cells in K5-SPT-KO mice. Therefore, we conclude that ceramide deficiency in the epidermis results in the development of psoriasis-like lesions.
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Research Products
(42 results)
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[Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model2011
Author(s)
Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S
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Journal Title
J Immunol
Volume: 186
Pages: 4481-4489
Peer Reviewed
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[Journal Article] Stat3 as a therapeutic target for the treatment of psoriasis. A clinical feasibility study with STA-21, a Stat3 Inhibitor2011
Author(s)
Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, Digiovanni J, Sano S
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Journal Title
J Invest Dermatol
Volume: 131
Pages: 108-117
Peer Reviewed
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[Presentation] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis2011
Author(s)
Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair R P, Voorhees J J, Elder JT, Wang X-J, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE.
Organizer
The 71th Annual Meeting of the Society for Investigative Dermatology
Place of Presentation
Phenix, U. S. A
Year and Date
20110504-07
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