Elucidation of the mechanism for development and infiltration of cutaneous squamous cell carcinoma

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyushu University
• Principal Investigator: FURUE Masutaka 九州大学, 医学研究院, 教授 (70134583)
• Co-Investigator(Kenkyū-buntansha): TAKAHARA Masakazu 九州大学, 大学病院, 講師 (20398093)
• Project Period (FY): 2009 – 2011
• Keywords: 皮膚悪性腫瘍 / CD10 / Snail / EMT / 線維芽細胞 / SATB1 / アルギナーゼ

Research Abstract

We demonstrated that IL-1αproduction by cutaneous squamous cell carcinoma(SCC) induced CD10 expression in the stromal fibroblast. The CD10-bearing fibroblast inhibited the invasive capacity of SCC by diminishing the microenvironmental concentration of substance P that supports tumor invasion via metalloproteinase induction.
Cathepsin K expression was detected in peritumoral fibroblasts around SCC, but not in those surrounding benign epidermal tumors. The CTSK-upregulated fibroblasts generated by SCC-derived IL-1αaugmented the matrigel invasive ability of SCC cells.
Taken together, these results highlighted the novel mechanism of stromal fibroblast playing important roles in cutaneous SCC invasion.

Research Products

• [Journal Article] Stromal expression of cathepsin K in squamous cell carcinoma (2011)
  • Author(s): Xiaofeng Yan, Masakazu Takahara, Lining Xie, Yoshinao Oda, Takeshi Nakahara, Hiroshi Uchi, Satoshi Takeuchi, Yating Tu, Yoichi Moroi, Masutaka Furue
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 25(3) Pages: 362-5
• [Journal Article] CD10-bearing fibroblasts may inhibit skin inflammation by down-modulating substance P (2011)
  • Author(s): Lining Xie, Masakazu Takahara, Takeshi Nakahara, Junna Oba, Hiroshi Uchi, Satoshi Takeuchi, Yoichi Moroi, Masutaka Furue
  • Journal Title: CD10-bearing fibroblasts may inhibit skin inflammation by down-modulating substance P Volume: 303(1) Pages: 49-55
• [Journal Article] CD10 expressed by fibroblasts and melanoma cells degrades endothelin-1 secreted by human keratinocytes (2011)
  • Author(s): Xie L, Moroi Y, Takahara M, Tsuji G, Oba J, Hayashida S, Takeuchi S, Shan B, Uchi H, Furue M
  • Journal Title: Eur J Dermatol Volume: 21(4) Pages: 505-9
• [Journal Article] Junna Oba, Takeshi Nakahara, Sayaka Hayashida, Makiko Kido, Lining Xie, Masakazu Takahara, Hiroshi Uchi, Shogo Miyazaki, Takeru Abe, Akihito Hagihara, Yoichi Moroi, Masutaka Furue (2011)
  • Author(s): Junna Oba, Takeshi Nakahara, Sayaka Hayashida, Makiko Kido, Lining Xie, Masakazu Takahara, Hiroshi Uchi, Shogo Miyazaki, Takeru Abe, Akihito Hagihara, Yoichi Moroi, Masutaka Furue
  • Journal Title: J Am Acad Dermatol Volume: 65(6) Pages: 1152-60
• [Journal Article] Cathepsin K-upregulation in fibroblasts promotes matrigel invasive ability of squamous cell carcinoma cells via tumor-derived IL-1α (2011)
  • Author(s): Xie L, Moroi Y, Hayashida S, Tsuji G, Takeuchi S, Shan B, Nakahara T, Uchi H, Takahara M, Furue M
  • Journal Title: J Dermatol Sci Volume: 61(1) Pages: 45-50
• [Journal Article] CD10-bearing fibroblast inhibits matrigel invasive potency of interleukin-1α-producing squamous cell carcinoma by diminishing substance P levels in the tumor microenvironment (2010)
  • Author(s): Xie L, Moroi Y, Tsuji G, Liu M, Hayashida S, Takahara M, Fukagawa S, Takeuchi S, Shan B, Nakahara T, Uchi H, Yokomizo T, Furue M
  • Journal Title: Cancer Sc Volume: 101(12) Pages: 2570-8
• [Journal Article] Expression of cathepsin K in neurofibromatosis 1-associated cutaneous malignant peripheral nerve sheath tumors and neurofibromas (2010)
  • Author(s): Xiaofeng Yan, Masakazu Takahara, Long Dugu, Lining Xie, Chisato Gondo, Makoto Endo, Yoshinao Oda, Takeshi Nakahara, Hiroshi Uchi, Satoshi Takeuchi, Yating Tu, Yoichi Moroi, Masutaka Furue
  • Journal Title: J Dermatol Sci Volume: 58(3) Pages: 227-9
• [Journal Article] Cathepsin K expression : a useful marker for the differential diagnosis of dermatofibroma and dermatofibrosarcomaprotuberans (2010)
  • Author(s): Xiaofeng Yan, Masakazu Takahara, Lining Xie, Yating Tu, Masutaka Furue
  • Journal Title: Histopathology Volume: 57(3) Pages: 486-8
• [Presentation] 22nd World Congress of Dermatology (2011)
  • Author(s): Cathepsin K expression in skin tumors. Masakazu TAKAHARA, Xiaofeng YAN, Yoichi MOROI, Masutaka FURUE
  • Organizer: Seoul
  • Place of Presentation: Korea
  • Year and Date: 2011-05-28
• [Presentation] 悪性末梢神経鞘腫瘍と神経線維腫におけるカテプシンK発現の検討 (2010)
  • Author(s): 師井洋一, Xiaofeng Yan,高原正和,古江増隆
  • Organizer: H22神経皮膚症候群に関する調査研究班会議
  • Place of Presentation: 東京
  • Year and Date: 2010-12-17
• [Presentation] 古江増隆NF-1に生じた悪性末梢神経鞘腫瘍と神経線維腫におけるカテプシンK発現の検討 (2010)
  • Author(s): Xiaofeng Yan、高原正和、Long Dugu、Lining Xie、小田義直、師井洋一
  • Organizer: 第2回日本レックリングハウゼン病学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-14
• [Presentation] 有棘細胞癌の間質に発現するCD10の役割 (2010)
  • Author(s): 師井洋一,謝立寧,古江増隆
  • Organizer: 九州基礎皮膚科研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-11-06
• [Presentation] Cathepsin K expression : a useful marker for the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans (2010)
  • Author(s): Masakazu Takahara, Xiaofeng Yan, Lining Xie, Yating Tu, Masutaka Furue
  • Organizer: Cathepsin K expression : a useful marker for the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans
  • Place of Presentation: 福岡市
  • Year and Date: 2010-10-01
• [Remarks] ホームページ
  • URL: http://www.kyudai-derm.org/