Development of new therapeutic strategy for skin cancers targeting CD147/Basigin

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591438
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kagoshima University
• Principal Investigator: KANEKURA Takuro 鹿児島大学, 医歯学総合研究科, 教授 (70177509)
• Project Period (FY): 2009 – 2011
• Keywords: CD147/Basigin / 皮膚癌 / 治療

Research Abstract

We revealed that CD147/basigin promotes proliferation, invasion, and metastasis of malignant melanoma through regulating tumor cell glycolysis and regulates tumor cell adhesion to matrix through phosphorylating the focal adhesion kinase(FAK), a downstream kinase of integrin that co-localizes with CD147 on the cell surface. These findings demonstrate that CD147/basigin could be a target molecule for new therapeutic strategy for skin cancers.

Research Products

• [Journal Article] Demethylation of TNFSF7 contributes to CD70 overexpression in CD4^+T cells from patients with systemic sclerosis (2012)
  • Author(s): Jiang H, Xiao R, Lian X, Kanekura T, Luo Y, Yin Y, Zhang G, Ynag Y, Wang Y, Zhao M, Lu Q.
  • Journal Title: Clin Immunol Volume: 143 Pages: 39-44
  • Peer Reviewed
• [Journal Article] CD147-targeting siRNA inhibits cell-matrix adhesion of human malignant melanoma cells by phosphrylating focal adhesion kinase (2012)
  • Author(s): Nishibaba R, Higashi Y, Su J, Furukawa T, Kawai K, Kanekura T.
  • Journal Title: J Dermatol Volume: 39 Pages: 63-7
  • Peer Reviewed
• [Journal Article] Role for E-cadherin as an inhibitory receptor on epidermalγδT cells (2011)
  • Author(s): Uchida Y, Kawai K, Ibusuki A, Kanekura T.
  • Journal Title: J Immunol Volume: 186 Pages: 6945-54
  • Peer Reviewed
• [Journal Article] Retinoic acid exhibits anti-fibrotic activity via the inhibition of 5-lipoxygenase expression in scleroderma fibroblasts (2011)
  • Author(s): Xiao R, Kanekura T, Yoshida N, Higashi Y, Lu QJ, Fukushige T, Kanzaki T.
  • Journal Title: J Dermatol Volume: 38 Pages: 345-53
  • Peer Reviewed
• [Journal Article] ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB (2010)
  • Author(s): Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T.
  • Journal Title: Biochem Biophys Res Commun Volume: 397 Pages: 350-4
  • Peer Reviewed
• [Journal Article] Depletion of CD147 sensitizes human malignant melanoma cells to hydrogen peroxide-induced oxidative stress (2010)
  • Author(s): Li J, Peng L, Wu L, Kuang Y, Su J, Yi M, Hu X, Li D, Xie H, Kanekura T, Chen X.
  • Journal Title: J Dermatol Sci Volume: 58 Pages: 204-10
  • Peer Reviewed
• [Journal Article] CD147 is highly expressed on peripheral blood neutrophils from patients with psoriasis and induces neutrophil chemotaxis (2010)
  • Author(s): Lu H, Kuang Y, Su J, Chang J, Wu L, Kanekura T, Li D, Chen M, Chen X.
  • Journal Title: J Dermatol Volume: 37 Pages: 1053-6
  • Peer Reviewed
• [Journal Article] CD147/basigin promotes progression of malignantmelanoma and other cancers (2010)
  • Author(s): Kanekura T, Xiang Chen
  • Journal Title: J Dermatol Sci Volume: 57 Pages: 149-154
• [Journal Article] RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion (2009)
  • Author(s): Kuang Y-H, Chen X, Su J, Wu L-S, Liao L-Q, Li-D, Chen Z-S, Kanekura T.
  • Journal Title: Cancer Lett Volume: 276 Pages: 189-95
  • Peer Reviewed
• [Journal Article] DNA demethylation of CD40L in CD4^+T-cells from women with systemic sclerosis-A possible explanation for female susceptibility
  • Author(s): Lian X, Xiao R, Hu X, Kanekura T, Jiang H, Li Y, Wang Y, Yang Y, Zhao M, Lu Q.
  • Journal Title: Arthritis Rheum Volume: (in press)
  • Peer Reviewed
• [Presentation] The treatment of the neutrophilic dermatoses. Symposium 44 : Neutrophilic dermatoses (2011)
  • Author(s): Kanekura T.
  • Organizer: The 22nd World Congress of Dermatology
  • Place of Presentation: Seoul
  • Year and Date: 20110524-29
• [Presentation] Treatment of pustular psoriasis and neutrophilic dermatoses (2011)
  • Author(s): Kanekura T.
  • Organizer: The 15th Annual Meeting of the Korean Society for psoriasis
  • Place of Presentation: Seoul
  • Year and Date: 2011-09-24
• [Presentation] CD147/basiginと癌日本皮膚科学会東北六県合同地方会学術大会 (2011)
  • Author(s): 金蔵拓郎
  • Organizer: 第353回例会
  • Place of Presentation: 仙台市
  • Year and Date: 2011-02-05
• [Presentation] E-cadherin on epidermalγδT cells is an inhibitory receptor (2010)
  • Author(s): Uchida Y, Kawai K, Kanekura T.
  • Organizer: The 40th Annual Meeting of European Society for Dermatological Reseach
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 20100908-11
• [Presentation] ER signaling is activated to protect human keratinocytes from ER stress provoked by the environmental dose UVB (2010)
  • Author(s): Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T.
  • Organizer: The 40th Annual Meeting of European Society for Dermatological Reseach
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 20100908-11
• [Presentation] A CD-147-targeting siRNA enhances the cell adhesion of human malignant cells by phosphorylating focal adhesion kinase (2010)
  • Author(s): Kamiwada R, Higashi Y, Kawai K, Kanekura T.
  • Organizer: The 70th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20100505-08
• [Presentation] CD147/Basiginと皮膚癌 (2009)
  • Author(s): 金蔵拓郎
  • Organizer: 第54回日本皮膚科学会高知地方会
  • Place of Presentation: 高知市
  • Year and Date: 2009-09-19
• [Presentation] 好中球と皮膚疾患 (2009)
  • Author(s): 金蔵拓郎
  • Organizer: 平成21年度日本皮膚科学会西部支部主催生涯教育セミナー
  • Place of Presentation: 福岡市
  • Year and Date: 2009-06-27