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2011 Fiscal Year Final Research Report

The relationship of cutaneous carcinogenesis and polymorphisms in the pigment-regulating genes including MC1R and P

Research Project

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Project/Area Number 21591449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKinki University

Principal Investigator

OISO Naoki  近畿大学, 医学部, 講師 (10419814)

Project Period (FY) 2009 – 2011
Keywords遺伝子 / 癌
Research Abstract

The aging society in Japan brings increased affected number of individuals with malignant cutaneous tumors. Sun exposure is the most essential environmental factor inducing cutaneous precancerosis and malignant tumors. Recent studies for inherited pigment anomalies identified the genes regulating skin color. We are currently investigating the relationship of cutaneous carcinogenesis and polymorphisms in the pigment-regulating genes including MC1R and P. This study would identify the Japanese subgroup to be recommended to protect sun exposure more intensively.

  • Research Products

    (36 results)

All 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (14 results) Book (2 results)

  • [Journal Article] The histopathological feature of the nail isthmus in an ectopic nail2011

    • Author(s)
      Oiso N, Kurokawa I, Tsuruta D, et al.
    • Journal Title

      Am J Dermatopathol

      Volume: 33 Pages: 841-844

    • Peer Reviewed
  • [Journal Article] Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families2011

    • Author(s)
      Narita T, Oiso N, Fukai K, et al.
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 505-508

    • Peer Reviewed
  • [Journal Article] Repigmantation of leukoderma of piebald patient associated with a novel mutation, G592E of tyrosine kinase domain within the c-kit gene2011

    • Author(s)
      Arase N, Wataya-Kaneda M, Oiso N, et al.
    • Journal Title

      J Dermatol Sci

      Volume: 64 Pages: 147-149

    • Peer Reviewed
  • [Journal Article] Skin ulcer mimicking pyoderma gangrenosum in a patient with incontinentia pigmenti2011

    • Author(s)
      Yoshida M, Oiso N, Kimura M, et al.
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 1019-1021

    • Peer Reviewed
  • [Journal Article] The diagnostic usefulness of dermoscopy for nevus depigmentosus2011

    • Author(s)
      Oiso N, Kawada A
    • Journal Title

      Eur J Dermatol

      Volume: 21 Pages: 639-640

    • Peer Reviewed
  • [Journal Article] Superimposed linear graft-versus-host disease and secondary cutaneous involvement of anaplastic large cell lymphoma2011

    • Author(s)
      Oiso N, Tatsumi Y, Rai S, et al.
    • Journal Title

      Eur J Dermatol

      Volume: 21 Pages: 636-638

    • Peer Reviewed
  • [Journal Article] Consequences of two different amino acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis2011

    • Author(s)
      Natsuga K, Nishie W, Smith BJ, et al.
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 1869-1876

    • Peer Reviewed
  • [Journal Article] Non-segmental vitiligo and autoimmune mechanism2011

    • Author(s)
      Oiso N, Suzuki T, Fukai K, et al.
    • Journal Title

      Dermatol Res Pract

      Pages: 518090

    • Peer Reviewed
  • [Journal Article] Two children with a mild or moderate piebaldism phenotype and a father with no leukoderma in a family with the same recurrent missense mutation in the kinase domain of KIT2011

    • Author(s)
      Narita T, Oiso N, Fukai K, et al.
    • Journal Title

      Eur J Dermatol

      Volume: 21 Pages: 446-447

    • Peer Reviewed
  • [Journal Article] Hyperpigmented spots within and partly around a hypopigmented macule2011

    • Author(s)
      Oiso N, Amatsu A, Kawada A
    • Journal Title

      Int J Dermatol

      Volume: 50 Pages: 795-797

    • Peer Reviewed
  • [Journal Article] Melanocytic nevi in nevus depigmentosus in a region of the body exposed to sunlight2011

    • Author(s)
      Oiso N, Kawada A
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 25 Pages: 491-492

    • Peer Reviewed
  • [Journal Article] Dermoscopic features in a case of dyschromatosis symmetrica hereditaria2011

    • Author(s)
      Oiso N, Murata I, Hayashi M, et al.
    • Journal Title

      J Dermatol

      Volume: 38 Pages: 91-93

    • Peer Reviewed
  • [Journal Article] Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR12010

    • Author(s)
      Nakayama T, Watanabe Y, Oiso N, et al.
    • Journal Title

      J Immunol

      Volume: 185 Pages: 6472-6479

    • Peer Reviewed
  • [Journal Article] The effectiveness of intense pulsed light for possible Riehl's melanosis2010

    • Author(s)
      Oiso N, Tsuruta D, Imanishi H, et al.
    • Journal Title

      Dermatol Ther

      Volume: 23 Pages: 561-563

    • Peer Reviewed
  • [Journal Article] Mutation Analysis of Patients with Dyschromatosis Symmetrica Hereditaria : Five Novel Mutations of the ADAR1 Gene2010

    • Author(s)
      Murata I, Hayashi M, Hozumi Y, et al.
    • Journal Title

      J Dermatol Sci

      Volume: 58 Pages: 518-520

    • Peer Reviewed
  • [Journal Article] A case of amelanotic vulvar melanoma with intratumor histological heterogeneity2010

    • Author(s)
      Oiso N, Yoshida M, Kawara S, et al.
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 537-541

    • Peer Reviewed
  • [Journal Article] Phylloid hypermelanosis and melanocytic nevi with aggregated and disfigured melanosomes : causal relationship between the phylloid pigment distribution and chromosome 13 abnormalities2010

    • Author(s)
      Oiso N, Tsuruta D, Imanishi H, et al.
    • Journal Title

      Dermatology

      Volume: 220 Pages: 169-172

    • Peer Reviewed
  • [Journal Article] A Japanese piebald patient with auburn hair color associated with a novel mutation p. P832L in the KIT gene and a homozygous variant p. I120T in the MC1R gene2009

    • Author(s)
      Oiso N, Kishida K, Fukai K, et al.
    • Journal Title

      Brit J Dermatol

      Volume: 161 Pages: 468-469

    • Peer Reviewed
  • [Journal Article] Pigmented spots as a sign of mammary Paget disease2009

    • Author(s)
      Oiso N, Kawara S, Inui H, et al.
    • Journal Title

      Clin Exp Dermatol

      Volume: 34 Pages: 36-38

    • Peer Reviewed
  • [Journal Article] Pigmentary mosaicism with hyperpigmented streaks on the palmoplantar lesion associated with balanced X ; autosome translocations t(X ; 9)(p11.21 ; q34.1)2009

    • Author(s)
      Oiso N, Amatsu A, Kawara S, et al.
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 23 Pages: 359-361

    • Peer Reviewed
  • [Presentation] Epidemiologic evaluation for non-segmental vitiligo and related autoimmune disorders in the Japanese population2011

    • Author(s)
      Oiso N, Fukai K, Narita T, et al.
    • Organizer
      The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20111209-11
  • [Presentation] Blastic plasmacytoid dendritic cell neoplasm caused by loss of genomic DNA copy numbers in the p18, p16, p27 and RB loci2011

    • Author(s)
      Oiso N, Tatsumi Y, Arao T, et al.
    • Organizer
      The 12th International Congress of Human Genetics & The American Society of Human Genetics 61st Annual Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      20111011-15
  • [Presentation] Generalized vitiligo and related autoimmune disorders in Japanese patients and their families2011

    • Author(s)
      Oiso N, Fukai K, Narita T, et al.
    • Organizer
      XXIst International Pigment Cell Conference
    • Place of Presentation
      Bordeaux, France
    • Year and Date
      20110920-24
  • [Presentation] シンポジウムTreatment strategies for mucocutaneous side effects caused by chemotherapeutic agents of small molecules and mononuclonal antibodies2011

    • Author(s)
      Oiso N
    • Organizer
      第9回日本臨床腫瘍学会学術大会
    • Place of Presentation
      横浜市
    • Year and Date
      20110721-23
  • [Presentation] The diagnostic application of dermoscopy for six-legged larval ticks2011

    • Author(s)
      Oiso N, Wada T, Yamamoto H, et al.
    • Organizer
      22nd Would Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20110524-29
  • [Presentation] 教育講演白斑の基礎と臨床2011

    • Author(s)
      大磯直毅
    • Organizer
      第110回日本皮膚科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      20110415-17
  • [Presentation] シンポジウム:「アレルギー疾患診療医間のパートナーシップの向上~総合アレルギー医を目指して~」皮膚科医の立場から2011

    • Author(s)
      大磯直毅
    • Organizer
      第67回臨床アレルギー研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-06-25
  • [Presentation] Histopathological and ultrastracural study for a Japanese female child case of erythema dyschromicum perstans2010

    • Author(s)
      Oiso N, Tsuruta D, Imanishi H, et al.
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama, Japan
    • Year and Date
      20101203-05
  • [Presentation] ランチョンセミナー「白斑の治療」汎発型尋常性白斑の疾患感受性遺伝子と治療2010

    • Author(s)
      大磯直毅
    • Organizer
      第23回日本色素細胞学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      20101122-23
  • [Presentation] Dyschromatosis symmetrica hereditaria : consideration of the pathogenesis with dermoscopic features2010

    • Author(s)
      Oiso N, Murata I, Hayashi M, et al.
    • Organizer
      The American Society of Human Genetics 60th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      20101102-06
  • [Presentation] Pigmented spots on the nipple : a sign of mammatory Paget disease2010

    • Author(s)
      Oiso N, Kawara S, Kawaka A
    • Organizer
      The First Eastern Asia Dermatology Congress
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20100930-1003
  • [Presentation] シンポジウム白斑とシミ尋常性白斑の疾患感受性遺伝子と治療2010

    • Author(s)
      大磯直毅
    • Organizer
      第61回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      20100911-12
  • [Presentation] 教育講演新しい検査(エコー・発汗検査を含む)新しい遺伝子検査と診断への応用2010

    • Author(s)
      大磯直毅
    • Organizer
      第109回日本皮膚科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      20100416-18
  • [Presentation] Mild phenotype of the dominant negative mutation in the tyrosine kinase domain of KIT may suggest a second modifier gene for piebaldism2009

    • Author(s)
      Oiso N, Suzuki T, Fukai K, et al.
    • Organizer
      The American Society of Human Genetics 59th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      20091020-24
  • [Book] 皮膚科診療カラ-アトラス大系72011

    • Author(s)
      大磯直毅
    • Total Pages
      160
    • Publisher
      講談社
  • [Book] The Stage of Melanogenesis in Amelanotic Melanoma. Melanoma in the Clinic. Diagnosis, management and Complications of Malignancy2011

    • Author(s)
      Oiso N, Kawada A, Murph M
    • Total Pages
      277-286
    • Publisher
      INTECH

URL: 

Published: 2013-07-31  

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