2011 Fiscal Year Final Research Report
Identification of melanoma-specific serum biomarker and its clinical application
| Project/Area Number |
21591451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shizuoka Cancer Center Research Institute |
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Principal Investigator |
AKIYAMA Yasuto 静岡県立静岡がんセンター(研究所), 免疫治療研究部, 部長 (70222552)
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOHARA Yoshio 静岡がんセンター病院, 皮膚科, 部長 (70205037)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メラノーマ / バイオマーカー / プロテオーム |
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| Research Abstract |
We identified pro-platlet basic protein precursor(PPBP) as novel melanoma-biomarker previously. In the present study, we are aiming at developing specific anti-PPBP antibody and establish PPBP-specific ELISA system contributing to a clinical application. The conventional method to make hybridoma using spleen cells was not successful ; however novel approach using regional lymph node enabled us to obtain many functional hybridoma clones. We plan to construct a high sensitive ELISA specific for PPBP through a screening of newly obtained hybridomas.
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Research Products
(17 results)
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[Journal Article] Identification of cytomegalovirus(CMV) pp65 antigenspecific human monoclonal antibodies using single B cell-based antibody gene cloning from melanoma patients2011
Author(s)
Iizuka A, Komiyama M, Tai S, Oshita C, Kurusu A, Kume A, Ozawa K, Nakamura Y, Ashizawa T, Yamamoto A, Yamazaki N, Yoshikawa S, Kiyohara Y, Yamaguchi K, Akiyama Y
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Journal Title
Immunol Lett
Volume: 135
Pages: 64-73
Peer Reviewed
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[Journal Article] Antitumor activity of a novel small molecule STAT3 inhibitor2011
Author(s)
Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A, and Akiyama Y
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Journal Title
Int J Oncol
Volume: 38(5)
Pages: 1245-52
Peer Reviewed
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[Journal Article] Identification of melanoma antigens using SERPA(serological proteome approach)2010
Author(s)
Suzuki A, Iizuka A, Komiyama M, Takikawa M, Kume A, Tai S, Ohshita C, Kurusu A, Nakamura Y, Yamamoto A, Yamazaki N, Yoshikawa S, Kiyohara Y, Akiyama Y
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Journal Title
Cancer Genomics and Proteomics
Volume: 7(1)
Pages: 17-23
Peer Reviewed
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[Journal Article] Identification of a new series of STAT3 inhibitors by virtual screening2010
Author(s)
Matsuno K, Masuda Y, Uehara Y, Sato H, Muroya A, Takahashi O, Yokotagawa T, Furuya T, Okawara T, Otsuka M, Ogo N, Ashizawa T, Oshita C, Tai S, Ishii H, Akiyama Y, Asai A
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Journal Title
ACS Med Chem Lett
Volume: 1(8)
Pages: 371-375
Peer Reviewed
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