2011 Fiscal Year Final Research Report
Elucidation of pathogenesis of DSH with the model mouse that melanocyte is distributed in epidermis
| Project/Area Number |
21591460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
KONO Michihiro 名古屋大学, 医学系研究科, 講師 (60319324)
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| Co-Investigator(Kenkyū-buntansha) |
MASAKI Sawada 名古屋大学, 医学部附属病院, 助教 (80467315)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 色素細胞学 |
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| Research Abstract |
1）ADAR1 p150 isoform specific knockout mice were constructed and the investigation of phenotype of the heterozygous mice was done.
（2）The SCF-transgenic (Tg) mouse and p150-Adar1-KO mouse were crossbred and the SCF-Tg/p150-Adar1-KO mouse that melanocyte was present in the epidermis was manufactured as a candidate of DSH model mouse. The phenotype of the mouse was examined.
（3）Eight novel mutations in ADAR1 which caused in Dyschromatosis symmetrica hereditaria were identified.
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[Journal Article] Four novel mutations of the ADAR1 gene in dyschromatosis symmetrica hereditaria.2009
Author(s)
Ichidai Murata, Yutaka Hozumi, Masakazu Kawaguchi, Yoshiyuki Katagiri, Shinichiro Yasumoto, Yoshiaki Kubo, Wataru Fujimoto, Tatsuya Horikawa, Taisuke Kondo, Michihiro Kono, Yasushi Tomita, Tamio Suzuki.
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Journal Title
J Dermatol Sci
Volume: 53(1)
Pages: 76-77
Peer Reviewed
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