2010 Fiscal Year Final Research Report
Analysis of novel homeostatic regulator of the skin.
| Project/Area Number |
21591464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
KATAYAMA Ichiro Osaka University, 医学系研究科, 教授 (80191980)
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| Co-Investigator(Kenkyū-buntansha) |
KIRA Masahiro 大阪大学, 大学院・医学系研究科, 講師 (90314335)
MTROTA Hiroyuki 大阪大学, 大学院・医学系研究科, 助教 (90363499)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 皮膚生理学 / 11βHSD1と皮膚の恒常性 / グルココルチコイド / アレルギー / 発ガン |
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| Research Abstract |
The role of 11βHSD1 in skin homeostasis was studied. The mRNA expression and protein level of 11βHSD1 increased by stimuli, such as UVB, haptens, and TNFα. 11βHSD1 knockdown by si11βHSD1 and 11βHSD1 inhibition by specific inhibitor suppressed differentiation of keratinocytes and enhanced proliferation. In vivo studies, selective inhibitor of 11βHSD1 promoted cutaneous wound healing. Taken together, we consider that 11βHSD1 acting as a regulator of keratinocytes proliferation and differentiation.
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