Development of the therapy for psoriasis by using mouse model

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591476
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kochi University
• Principal Investigator: TARUTANI Masahito 高知大学, 教育研究部・医療学系, 准教授 (30301261)
• Project Period (FY): 2009 – 2011
• Keywords: Raf / IL-17乾癬 / モデルマウス / Stat3

Research Abstract

Psoriasis-like skin hyperkeratosis appeared by expressing Raf protein in mice skin by using tamoxifen induced Raf transgenic mice. And the cytokines, which increase in psoriatic skin also elevated in these mice skin. As neutrophil infiltration was seen in these Raf induced skin hyperkeratosis, we treated these mice with anti-neutrophil antibody. The result is that hyperkeratosis was diminished. Next, we disrupted Stat3 in these Raf induced mouse skin using stat3 knockout mice, then Raf-induced skin hyperkeratosis was diminished. These data suggest that Stat3 plays an important role for the pathogenesis of Raf induced psoriasis-like mouse skin hyperkeratosis

Research Products

• [Journal Article] Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S. Stat3 as a therapeutic target for the treatment of psoriasis : a clinical feasibility study with STA-21, a Stat3 inhibitor (2011)
  • Author(s): Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S.
  • Journal Title: J Invest Dermatol Volume: 131(1) Pages: 108-117
  • Peer Reviewed
• [Journal Article] Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice (2010)
  • Author(s): Tarutani M, Imai Y, Yasuda K, Tsutsui H, Nakanishi K, Yamanishi K.
  • Journal Title: J Dermatol S Volume: 58(1) Pages: 28-35
  • Peer Reviewed
• [Presentation] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation (2011)
  • Author(s): Tarutani M, Miyoshi K, Takaishi M and Sano S
  • Organizer: 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20111209-11
• [Presentation] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation. 71st annual meeting of the society for investigative dermatology, Concurrent Minisymposium 3 (2011)
  • Author(s): Tarutani M, Miyoshi K, Takaishi M and Sano S
  • Organizer: Epidermal Structure and Function
  • Place of Presentation: Phoenix, Arizona, U. S. A.
  • Year and Date: 20110504-07
• [Presentation] Rafの活性化により引き起こされる乾癬様皮疹はStat3シグナルを必要とする (2011)
  • Author(s): 樽谷勝仁,他
  • Organizer: 第26回角化症研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-30
• [Presentation] 乾癬、掌蹠膿疱症の新しい病因論と治療乾癬の病因論2010 (2010)
  • Author(s): 樽谷勝仁
  • Organizer: 第109回日本皮膚科学会総会、教育講演
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-20
• [Presentation] Neutrophil-dominant psoriasis-like skin inflammation induced by epidermis-specific Raf expression in mice, 39th Annual ESDR Meeting (2009)
  • Author(s): Tarutani M, Imai Y, Tsuda T, Nakanishi K, Yamanishi K
  • Organizer: Poster presentation
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-09-12