2011 Fiscal Year Final Research Report
Behavioral and neuropharmacological study on neural plasticity induced by neural transplantation or L-DOPA therapy
| Project/Area Number |
21591486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Ryuichiro 宮崎大学, 医学部, 助教 (90336298)
ABE Hiroshi 宮崎大学, 医学部, 講師 (20344848)
NONAKA Hiroi 宮崎大学, 医学部, 助教 (30311591)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMORI Toshikazu 宮崎大学, 医学部, 教授 (20112211)
EBIHARA Kosuke 宮崎大学, 医学部, 助教 (20510720)
MATSUO Hisae 宮崎大学, 医学部, 助教 (70511476)
UEDA Yuto 宮崎大学, 医学部, 准教授 (70244192)
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| Project Period (FY) |
2009 – 2011
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| Keywords | パーキンソン病 / L-DOPA / 神経移植 / 転写調節因子 / 神経科学 |
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| Research Abstract |
A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene(IEG) proteins(FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine(6-OHDA) rat model of Parkinson's disease. During a course of chronic L-DOPA treatment, rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute L-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate(Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.
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[Journal Article] Effects of yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease2010
Author(s)
Okahara K, Ishida Y, Hayashi Y, InoueT, Tsuruta K, Takeuchi K, Yoshimuta H, KiueK, Ninomiya Y, Kawano J, Yoshida K, NodaS, Tomita S, Fujimoto M, Hosomi J, Mitsuyama Y
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 34-3
Pages: 532-536
Peer Reviewed
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[Journal Article] Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with yokukansan in clinical practice2010
Author(s)
Hayashi Y, Ishida Y, Inoue T, Udagawa M, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Sameshima T, Kawahara T, Goto I, Shudo K, Kurayama S, Nakamura J, Okahara K, Mitsuyama Y
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 34-3
Pages: 541-545
Peer Reviewed
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[Journal Article] Central endogenous vasopressin induced by central salt-loading participates in body fluid homeostasis through modulatory effects on neurons of the PVN in conscious rats2009
Author(s)
Kato K, Kannan H, Ohta H, Kemuriyama T, Maruyama S, Tandai-Hiruma M, Sato Y, Nakazato M, Nishimori T, Ishida Y, OnakaT, Nishida Y
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Journal Title
JNeuroendocrinol
Volume: 21-11
Pages: 921-934
Peer Reviewed
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[Presentation] A molluscan neuropeptide, APGWamide, shows the antiallodynic effect in the rat model of diabetic neuropathy2011
Author(s)
Ikeda T, Igawa K, Ishizuka Y, Nakamura K, Naono R, Takeda R, Ishida Y, Nishimori T
Organizer
41th Annual Meeting Society for Neuroscience
Place of Presentation
Washington, DC
Year and Date
20111112-16
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[Presentation] Epidemiological study of influences of long-term treatment with a traditional Japanese medicine, yokukansan, on behavioral and psychological symptoms of dementia2011
Author(s)
Okahara K, Fujino Y, Iwakiri S, Hayashi Y, Tsuchiya Y, Ishida Y
Organizer
American Psychiatric Association, 164th Annual Meeting
Place of Presentation
Honolulu, HI, USA
Year and Date
20110514-18
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