2011 Fiscal Year Final Research Report
Kicking and biting behavioral responses toward mechanical touch stimuli in stress-disorder model mouse
| Project/Area Number |
21591487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kagoshima University |
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Principal Investigator |
KUCHIIWA Satoshi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (90161637)
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| Project Period (FY) |
2009 – 2011
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| Keywords | うつ病 / 統合失調症 / 行動学研究 / 接触逃避行動 / 蹴り払い応答 / 対物攻撃行動 / 噛みつき応答 / イリタビリティ |
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| Research Abstract |
Irritability is a widely occurring DSM-IV symptom in patients with psychiatric disorders and/or developmental disorders. Behavioral symptoms of irritability also occur in laboratory psychiatric model animals such as stress and/or depression disorders. However, behavioral paradigms for estimation of irritability have not been reported in studies using laboratory animals. Establishment of protocols for estimation of irritability in psychiatric animal models is needed to study psychotropic drug evaluations. In the present study, we developed a new research apparatus that can detect and record intensities and incidence rates of touch escape behavior and aggressive behavior toward inanimate mechanical stimuli. We estimated irritability in chronically stressed mice and evaluated the effects of psychotropic drugs on irritability using the touch escape behavior and aggressive behaviors as paradigms. The present study suggests that both responses can be used as behavioral paradigms in quantitative analyses of irritability. Both paradigms appear to be useful for drug evaluation of psychotropic agents using the same individuals repeatedly.
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