Early diagnosis of Alzheimer's disease by amyloid PET and MRI

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tohoku University
• Principal Investigator: WARAGAI Masaaki 東北大学, 加齢医学研究所, 非常勤講師 (50533775)
• Co-Investigator(Kenkyū-buntansha): ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613) ; TOMITA Naoki 東北大学, 病院, 助教 (00552796)
• Project Period (FY): 2009 – 2011
• Keywords: アルツハイマー病 / 軽度認知障害 / アミロイドPET / BF-227 / 構造的MRI

Research Abstract

We studied subjects with non-demented controls, mild cognitive impairment(MCI)and early Alzheimer's disease using BF-227 PET and structural MRI. We found that BF-227 PET is useful for early diagnosis of MCI. We found that BF-227 PET is useful for early diagnosis for AD and structural MRI is suitable for tracking of disease progression of the disease. Amyloid deposition was not correlated with grey matter atrophy.

Research Products

• [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : comparison to FDG-PET (2010)
  • Author(s): Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, KudoY, Arai H.
  • Journal Title: J Neurol Volume: 257 Pages: 721-727
  • Peer Reviewed
• [Journal Article] Pathobiology of Alzheimer's disease and biomarker development (2010)
  • Author(s): Arai H, Okamura N, Waragai M, Furukawa K, Yanai K, Kudo Y
  • Journal Title: Nihon Yakurigaku Zasshi Volume: 135 Pages: 3-7
  • Peer Reviewed
• [Journal Article] α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson's Disease (2010)
  • Author(s): Waragai M, Sekiyama K, Sekigawa A, Takamatsu Y, Fujita M, Hashimoto M
  • Journal Title: Int J Mol Sci Volume: 11(11) Pages: 4257-66
  • Peer Reviewed
• [Journal Article] A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain (2010)
  • Author(s): Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M
  • Journal Title: Nat Commun Volume: Nov 2 Pages: 1-110
  • Peer Reviewed
• [Journal Article] P2X7 receptor signaling pathway as a therapeutic targetfor neurodegenerative diseases (2010)
  • Author(s): Takenouchi T, Sekiyama K, Sekigawa A, Fujita M, Waragai M, Sugama S, IwamaruY, Kitani H, Hashimoto M
  • Journal Title: Arch Immunol Ther Exp (Warsz) Volume: 58(2) Pages: 91-6
  • Peer Reviewed
• [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease (2009)
  • Author(s): Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H
  • Journal Title: J Neurol Sci Volume: 285 Pages: 100-108
  • Peer Reviewed
• [Journal Article] Gangliosides' protection against lysosomal pathology of synucleinopathies. (2009)
  • Author(s): Wei J, Fujita M, Sekigawa A, Sekiyama K, Waragai M, Hashimoto M
  • Journal Title: Autophagy Volume: 5(6) Pages: 860-1
  • Peer Reviewed
• [Journal Article] Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies (2009)
  • Author(s): Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
  • Journal Title: Am J Pathol Volume: 174(5) Pages: 1891-909
  • Peer Reviewed
• [Presentation] Amyloid PET in mild cognitive impairment and Alzheimer's disease with [11C] BF-227 : comparison to voxel-based morphometric MRI (2010)
  • Author(s): Waragai M, et al.
  • Organizer: Alzheimer's Association International Conference 2010 (AAIC)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] A study of correlation between the Mini Mental State Examination (MMSE)score, thegrey matter atrophy andpotentially Alzheimer's disease related plasma biomarkers (2010)
  • Author(s): Waragai M, et al.
  • Organizer: Alzheimer's Association International Conference 2010 (AAIC)
  • Place of Presentation: Paris, France
  • Year and Date: 2010-07-11
• [Book] 石灰沈着を伴うびまん性神経原線維変化病 (2011)
  • Author(s): 藁谷正明
  • Total Pages: 451-454
  • Publisher: 日本臨牀社