2011 Fiscal Year Final Research Report
Evaluation for CSF histamine levels in many disorders and measurements of hypothalamic neuropeptides in the patients with Kleine-Levin syndrome
| Project/Area Number |
21591501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
SHIMIZU Tetsuo 秋田大学, 大学院・医学系研究科, 教授 (90170977)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 過眠症 / ヒスタミン / オレキシン / Kleine-Levin症候群 / Agrp |
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| Research Abstract |
(1) We first reported that histamine decreases in the primary CNS hypersomnia, such as narcolepsy and idiopathic hypersomnia (Kanbayashi 2009). However, the histamine levels in other diseases are still unknown. We have further estimated the histamine in CSF of several neurological diseases. Histaminergic neurons are located exclusively in the tuberomammillary nucleus (TMN) of the posterior hypothalamus and project their axons to various brain regions. Histamine is released in the brain not only from TMN histamine neurons, but also from brain mast cell enriched in the choroid plexus, and peripheral blood transferred to central nervous system (CNS). Histamine release by these cells may contribute to CSF histamine levels. Increased CSF histamine levels have been reported in meningitis and encephalitis (Ito 2010). In the demyelinating diseases, histamine levels of MS were low but those of ADEM were high. In addition, we found reductions in CSF histamine levels in PSP and CBD compared to MSA (Kanbayashi2012). The differences of histamine levels in these disorders may be caused by the dysfunctions of posterior hypothalamus. (2) Kleine-Levin Syndrome (KLS) is a neurological disorder characterized by recurring periods of excessive amounts of sleeping and eating. We hypothesized that this disorder is caused by the damage to hypothalamic neuropeptides. The refore, we measured hypothalamic peptides and neurotransmitters, such as, αMSH, AgRP, MCH, nesfatin-1, orexin and histamine. There were no specific findings in the levels of neuropeptides and neurotransmitters (Kanbayashi2010). While we found that CSF AgRP were elevated in the patients with anorexia nervosa, the histamine levels are relatively low among the patiets with KLS (Ito2010).
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[Journal Article] Anti-NMDA-receptor antibody detected in encalitis, schizophrenia, and narcolepsy with psychotic features2012
Author(s)
Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Shuken Boku, Wakako Ito, Jun Tokunaga, Akane Mori, Yasuo Hishikawa, Tetsuo Shiizu, Seiji Nishino
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Journal Title
BMC Psychiatry
Volume: 12(1)
Pages: 37
Peer Reviewed
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[Journal Article] 抗NMDA受容体脳炎と診断された男性例2011
Author(s)
筒井幸, 徳永純, 森朱音, 近藤類, 岩谷光貴, 伏見進, 大川聡, 菅原純哉, 苗村育郎, 神林崇, 清水徹男
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Journal Title
精神科治療学
Volume: 26巻2号
Pages: 235-239
Peer Reviewed
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[Presentation] EVALUATION OF CSF HISTAMINE IN THE PATIENTS WITH NARCOLEPSY OR VARIOUS DISEASES2010
Author(s)
Ito W, Kanbayashi T, Kodama T, Kikuchi Y, Arii J, Shimizu K, Aizawa R, Chiba S, Yano T, Shimizu T
Organizer
Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
San Antonio, TX, USA
Year and Date
2010-06-07
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[Presentation] CSF MELANIN-CONCENTRATING HORMONECO NCENTRARION IN NARCOLEPSY AND VARIOUS NEUROOGICAL DISORDERS2010
Author(s)
Kanbayashi T, Ito W, Takemura T, Takemura F, Takahashi S, Sato M, HayY, Sagawa Y, Nishino S, Shimizu T
Organizer
Annual Meeting of the Associated Professional Sleep Soci ETIES
Place of Presentation
San Antonio, Tx, USA.
Year and Date
2010-06-07
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