Is there any common pathogenesis between autism spectrum disorder and bipolar disorder

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: MUNESUE Toshio 金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Mitsuru 金沢大学, 子どものこころの発達研究センター, 特任准教授 (00377384) ; KOSAKA Hirotaka 福井大学, 医学部子どもの発達研究センター, 特命准教授 (70401966)
• Project Period (FY): 2009 – 2011
• Keywords: 自閉症スペクトラム障害 / 双極性障害 / ロールシャッハ・テスト / 脳形態画像

Research Abstract

Rorschach ink blot reactions were examined among 39 subjects with autism spectrum disorder(ASD), 41 subjects with bipolar disorder(BD) and 52 healthy individuals, aged 15 to 29 year, respectively. The score of the valuables designated as' pure F%' and' FM' was significantly different in both the subjects with ASD and the subjects with BD compared to healthy individuals. The score of both valuables significantly correlated with the Autism-spectrum Quotient. Also, fractional anisotropy(FA) values were investigated preliminarily among these three groups using diffusion tensor imaging method. While FA value in the splenium of corpus callosum was significantly lower in subjects with BD than in subjects with ASD and healthy subjects, FA value was the lowest in subjects with ASD and comorbid BD.

Research Products

• [Journal Article] Language performance and auditory evoked fields in 2-to 5-year-old children (2012)
  • Author(s): Yoshimura, Y., Kikuchi, M., Shitamichi, K., Ueno, S., Remijn, G. B., Haruta, Y., Oi, M., Munesue, T., Tsubokawa, T., Higasida, H., Minabe, Y.
  • Journal Title: Eur. J. Neurosci Volume: 35 Pages: 644-650
  • Peer Reviewed
• [Journal Article] Social memory, amnesia, and autism : brain oxytocin secretion is regulated by NAD+and single nucleotide polymorphism of CD38 (2012)
  • Author(s): Higashida, H., Yokoyama, S., Huang, J.-J., Liu, L., Ma, W.-J., Akter, S., Higashida, C., Kikuchi, M., Minabe, Y., Munesue, T.
  • Journal Title: Neurochem. Int
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms in the CD38 gene encoding a critical molecule in oxytocin secretion and nasal oxytocin administration to subjects with autism spectrum disorders (2012)
  • Author(s): Higashida, H., Yokoyama, S., Kikuchi, M., Munesue, T.
  • Journal Title: Horm. Behav Volume: 61 Pages: 351-358
  • Peer Reviewed
• [Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders : an fMRI study (2012)
  • Author(s): Morita, T., Kosaka, H., Saito, D. N., Ishitobi, M., Munesue, T., Itakura, S., Omori, M., Okazawa, H., Wada, Y., Sadato, N.
  • Journal Title: Soc. Neurosci
  • Peer Reviewed
• [Journal Article] Lateralized theta wave connectivity and language performance in 2-to 5-year-oldchildren (2011)
  • Author(s): Kikuchi, M., Shitamichi, K., Yoshimura, Y., Ueno, S., Remijn, G. B., Hirosawa, T., Munesue, T., Tsubokawa, T., Haruta, Y., Oi, M., Higashida, H., Minabe, Y.
  • Journal Title: J. Neurosci Volume: 31 Pages: 14984-14988
  • Peer Reviewed
• [Journal Article] Time slip' phenomenon in adolescents and adults with autism spectrum disorders : case series (2011)
  • Author(s): Tochimoto, S., Kurata, K., Munesue, T.
  • Journal Title: Psychiatry Clin. Neurosci Volume: 65 Pages: 381-383
  • Peer Reviewed
• [Presentation] Oxytocin effect in young males with autism spectrum disorders : Aneye-tracking study (2011)
  • Author(s): Kosaka, H., Munesue, T., Saito, D. N., Fujii, T., Yanaka, H., Ishitobi, M., Asano, M., Narita, K., Murata, T., Omori, M., Okazawa, H., Sadato, N., Wada, Y.
  • Organizer: Joint Academic Conference on Autism Spectrum Disorders
  • Place of Presentation: 日本財団ビル(東京都)
  • Year and Date: 2011-12-02
• [Presentation] Similarities in Rorschach inkblot scores between patients with autism spectrum disorders and bipolar disorders (2011)
  • Author(s): Munesue, T., Muramatsu, T., Kikuchi, M., Higashida, H., Minabe, Y.
  • Organizer: Joint Academic Conference on Autism Spectrum Disorders
  • Place of Presentation: 日本財団ビル(東京都)
  • Year and Date: 2011-12-02
• [Presentation] Lateralized theta wave MEG coherence and language performance in 2-to 5-year-old children (2011)
  • Author(s): Kikuchi, M., Munesue, T., Higashida, H., Minabe, Y.
  • Organizer: Joint Academic Conference on Autism Spectrum Disorders
  • Place of Presentation: 日本財団ビル(東京都)
  • Year and Date: 2011-12-02
• [Presentation] シンポジウム「子どもの双極性障害」:子どもの双極性障害の治療:抗うつ薬によるactivation syndromeを含めて (2011)
  • Author(s): 棟居俊夫
  • Organizer: 第31回日本精神科診断学会
  • Place of Presentation: 信州大学医学部附属病院(長野県)
  • Year and Date: 2011-11-19
• [Presentation] 高機能自閉症スペクトラム成人の物語理解.日本自閉症スペクトラム学会 (2011)
  • Author(s): 米田英嗣、小坂浩隆、齋藤大輔、猪原敬介、棟居俊夫、岡沢秀彦
  • Organizer: 第10回記念研究大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-09-11
• [Presentation] Characeristics of adolescent with bipolar disorder as seen through of Rorschach test (2011)
  • Author(s): Muramatsu, T., Matsuo, C., Munesue, T.
  • Organizer: 14^<th> International Congress of European Society for Child and Adolescent Psychiatry
  • Place of Presentation: Finlania Hall(Finland)
  • Year and Date: 2011-06-13
• [Book] 双極性障害(I型・II型に分けて) (2012)
  • Author(s): 棟居俊夫
  • Publisher: 永井書店(印刷中)