2011 Fiscal Year Annual Research Report
FDG-PETによるDLB患者に対するコリンエステラーゼ阻害剤の効果判定法の開発
| Project/Area Number |
21591514
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| Research Institution | Osaka University |
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Principal Investigator |
数井 裕光 大阪大学, 医学系研究科, 講師 (30346217)
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| Co-Investigator(Kenkyū-buntansha) |
畑澤 順 大阪大学, 医学系研究科, 教授 (70198745)
足立 裕祥 大阪大学, 保健センター, 准教授 (00303785)
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| Keywords | レビー小体病 / 睡眠障害 / コリンエステラーゼ阻害薬 / アクチグラフ / FDG-PET |
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| Research Abstract |
目的:Dementia with Lewy bodies (DLB)患者に対して、コリンエステラーゼ阻害薬であるドネペジル投与後の認知機能、精神症状、睡眠状態の変化を明らかにした。またFDG-PET検査でブドウ糖代謝の変化を検討した。方法:対象はDLB患者9例(男/女4/5、平均年齢76.7±6.3歳、平均MMSEスコア18.9±5.2)と対照の健常高齢者(Normal control : NC)25名(男/女10/25、平均年齢73.3±3.3歳、平均MMSEスコア29.0±1.2)。DLB群に対しては、12週間のドネペジル投与前後に2回、NC群に対しては1回様々な臨床評価を行った。結果:DLB患者では、ドネペジル投与によりMMSE(18.9→22.7)、ADAS(16.7→10.9)、NPIの幻視(2.9→0.7)、睡眠(3.7→0.7)、認知機能の変動の指標であるMayo Fluctuations Questionnaire (MFQ)のスコア(2.6→0.3)、アクチグラフ(Sleepwatch-0, Ambulatory Monitoring)で計測した睡眠中の体動スコア(12342.4→8514.9)に統計学的に有意な改善を認めた。FDG-PET画像については、DLB患者ではNC群と比較すると、両側楔前部、右下頭頂小葉～右角回、左下～中側頭回、左内側前頭回、左下前頭回、右下前頭回、右上～中前頭回の低下を認めた。ドネペジル投与前と比較すると投与後には右楔前部～後部帯状回、左中前頭回～眼窩回、左楔前部～楔部で改善を認めた。結論:DLB患者では、コリンエステラーゼ阻害薬によって認知機能、精神症状、睡眠状態が改善し、かつ脳ブドウ糖代謝が改善する領域を認めた。
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Research Products
(48 results)
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[Journal Article] A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait2012
Author(s)
Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
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Journal Title
Neurosci Lett
Volume: (Epub ahead of print)
DOI
Peer Reviewed
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[Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
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Journal Title
PLoS One
Volume: 7(1)
Pages: e29780
DOI
Peer Reviewed
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[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage2011
Author(s)
Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
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Journal Title
Dement Geriatr Cogn Disord Extra
Volume: 1
Pages: 20-30
DOI
Peer Reviewed
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[Presentation] Classification of delusions in Alzheimer's disease and the neural correlates2011
Author(s)
Keiko Nomura, Hiroaki Kazui, Yumiko Kito, Tamiki Wada, Hiromichi Sugiyama, Daisuke Yamamoto, Kenji Yoshiyama, Hiromasa Tokunaga, Eku Shimosegawa, Jun Hatazawa, Masatoshi Takeda
Organizer
Korean Association for Geriatric Psychiatry annual meeting
Place of Presentation
Seoul, Korea(招待講演)
Year and Date
2011-11-18
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[Presentation] Classification of delusions in Alzheimer's disease2011
Author(s)
Keiko Nomura, H Kazui, Y Kito, M Takaya, T Wada, H Sugiyama, D Yamamoto, K Yoshiyama, H Tokunaga, K Tabushi, M Takeda
Organizer
International Psychogeriatric Association 15^<th> International Congress
Place of Presentation
Hague, Netherlands
Year and Date
2011-09-07
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[Presentation] 専門病院に入院に至るBPSDの前向き多施設共同調査2011
Author(s)
杉山博通, 数井裕光, 釜江(繁信)和恵, 正木慶大, 八田直己, 山本大介, 和田民樹, 野村慶子, 高屋雅彦, 吉山顕次, 田伏薫, 武田雅俊
Organizer
第26回日本老年精神医学会学術総会
Place of Presentation
東京
Year and Date
2011-06-16
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[Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo2011
Author(s)
Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi, Takeshi Morihara, Ryota Hashimoto, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
Organizer
10th World congress of biological Psychiatry
Place of Presentation
Prague, Czech Republic
Year and Date
2011-06-01
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[Presentation] Relationship of prepulse inhibition to personality dimensions in Japanese patients with schizophrenia2011
Author(s)
Hidetoshi Takahashi, Masao Iwase, Yuka Yasuda, Hidenaga Yamamori, Kazutaka Ohi, Motoyuki Fukumoto, Leonides Canuet, Ryouhei Ishii, Hiroaki Kazui, Ryota Hashimoto, Masatoshi Takeda
Organizer
10th World congress of biological Psychiatry
Place of Presentation
Prague, Czech Republic
Year and Date
2011-05-31
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[Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia2011
Author(s)
Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, Motoyuki Fukumoto, Hidenaga Yamamori, Kouzin Kamino, Takashi Morihara, Masao Iwase, Hiroaki Kazui, Masatoshi Takeda
Organizer
10th World congress of biological Psychiatry
Place of Presentation
Prague, Czech Republic
Year and Date
2011-05-31
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