2011 Fiscal Year Final Research Report
Effect of cholinesterase inhibitor on symptoms and cerebral glucose metabolism in patients with dementia with Lewy bodies
| Project/Area Number |
21591514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
KAZUI Hiroaki 大阪大学, 医学系・研究科, 講師 (30346217)
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| Co-Investigator(Kenkyū-buntansha) |
HATAZAWA Jun 大阪大学, 医学系・研究科, 教授 (70198745)
ADACHI Hiroyoshi 大阪大学, 保健センター, 准教授 (00303785)
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| Project Period (FY) |
2009 – 2011
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| Keywords | レビー小体病 / 睡眠障害 / 幻視 / FDG-PET / アクチグラフ / コリンエステラーゼ阻害薬 |
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| Research Abstract |
Cognitive function, neuropsychiatric symptoms, sleep disturbance, and cerebral glucose metabolism were evaluated in 9 patients with dementia with Lewy bodies before and after the administration of cholinesterase inhibitor(donepezil). Sleep disturbances were calculated from night-time activity, which was measured with a recording accelerometer called an ActiGraph. Cerebral glucose metabolism was measured with FDG-PET scan. Cognitive impairment, sleep disturbances, body movement during sleep, and hallucinations improved after donepezil treatment. Cerebral glucose metabolism in the right precuneus and posterior cingulated gyrus, and left middle frontal gyrus, orbitofrontal gyrus, precuneus, and cuneus improved after donepezil treatment.
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[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage2011
Author(s)
Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M.
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Journal Title
Dement Geriatr Cogn Disord Extra
Volume: 1
Pages: 20-30
DOI
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