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2011 Fiscal Year Final Research Report

The investigating the molecular mechanisms of cognitive impairment due to cancer chemotherapy and its prevention

Research Project

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Project/Area Number 21591515
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

TANIMUKAI Hitoshi  大阪大学, 大学院・医学系研究科, 特任助教(常勤) (60432481)

Co-Investigator(Kenkyū-buntansha) KUDO Takashi  大阪大学, 大学院・医学系研究科, 准教授 (10273632)
MORIHARA Takashi  大阪大学, 大学院・医学系研究科, 助教 (90403196)
OKAMOTO Yoshiaki  大阪大学, 大学院・薬学研究科, 講師 (90432442)
TSUGANE Mamiko  大阪大学, 大学院・薬学研究科, 助教 (00469991)
Project Period (FY) 2009 – 2011
Keywords認知機能障害 / 抗がん剤 / ケモブレイン / 小胞体ストレス / 予防
Research Abstract

To investigate the molecular mechanisms of chemotherapy induced cognitive impairment, we studied the neuronal toxicity(NT) of paclitaxel(Px), fluorouracil(5-FU), and cyclophosphamide(CPA) on neuronal culture cells(SY5Y and SK-N-SH) and further investigated its relationship to endoplasmic reticulum stress(ER stress). Significant NT was observed in cells treated with Px and 5-FU in dose dependent manner, but not with CPA. In addition, the induction of both p-eIF2αand GRP78/ 94 were observed in cells by Px or 5-FU treatment. Pre-treatment of cells with Bip inducer X(BIX) reduced Px-induced NT but not 5-FU induced NT. These data suggest that Px induced NT probably relates to ER stress and BIX could prevent the Px induced NT as including chemobrain.

  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] ER stress and neuropsychiatric disease2012

    • Author(s)
      Kudo T.
    • Journal Title

      ER stress and neuropsychiatric disease

      Volume: 114(2) Pages: 115-23

    • Peer Reviewed
  • [Journal Article] Sigma-1Rs are upregulated via PERK/ eIF2α/ ATF4 pathway and execute protective function in ER stress2011

    • Author(s)
      Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: Nov 25 ; 415(3) Pages: 519-25

    • Peer Reviewed
  • [Journal Article] Molecular chaperone inducer : a possible treatment for Alzheimer disease2011

    • Author(s)
      Kudo T.
    • Journal Title

      Rinsho Shinkeigaku

      Volume: Nov ; 51(11) Pages: 889

    • Peer Reviewed
  • [Journal Article] がん疼痛に伴う精神症状の評価とその対策2011

    • Author(s)
      谷向仁、壁下康信
    • Journal Title

      Progress in Medicine

      Volume: 31(5) Pages: 1235-1239

  • [Presentation] 血液がん患者における不眠の実態及び抑うつとの関連に関する研究2011

    • Author(s)
      谷向仁、平井啓、足立祥洋
    • Organizer
      第16回日本緩和医療学会学術大会
    • Place of Presentation
      札幌,日本
    • Year and Date
      2011-07-29
  • [Presentation] "A retrospective chart review of agitation in terminal cancer patients2011

    • Author(s)
      Okamoto Y, Nagase M, Tsuneto S, Tanimukai H, Matsuda Y, Okishiro N, Kumakura Y, Ono Y, Tsugane M, Takagi T, Uejima E.
    • Organizer
      12^<th> Congress of the European Association for Palliative Care
    • Place of Presentation
      Lisbon Congress Center, Portugal
    • Year and Date
      2011-05-20
  • [Presentation] Can Trazodone Improve Insomnia and Nightmare in Cancer Patients?: A Report of Two Cases2011

    • Author(s)
      Tanimukai H, Kumakura Y, Okishiro N, Matsuda Y, Okamoto Y, Kabeshita Y, Ohno Y, Tsuneto S.
    • Organizer
      12^<th> Congress of the European Association for Palliative Care
    • Place of Presentation
      Lisbon Congress Center, Portugal
    • Year and Date
      2011-05-19
  • [Presentation] がん患者にみられる様々な認知機能障害~せん妄を中心に~2010

    • Author(s)
      谷向仁
    • Organizer
      第6回北摂緩和医療懇話会
    • Place of Presentation
      大阪,日本
    • Year and Date
      2010-09-03

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Published: 2013-07-31  

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