MEG gamma network abnormality in schizophrenia

2012 Fiscal Year Final Research Report

• Project/Area Number: 21591516
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: ISHII Ryouhei 大阪大学, 医学系研究科, 助教 (40372619)
• Co-Investigator(Kenkyū-buntansha): IWASE Masao 大阪大学, 医学系研究科, 助教 (60362711) ; TAKEDA Masatoshi 大阪大学, 医学系研究科, 教授 (00179649)
• Project Period (FY): 2009 – 2012
• Keywords: 統合失調症 / 脳磁図 / ガンマ帯域活動 / ネットワーク異常 / 脆弱性遺伝子

Research Abstract

Twenty-two SCZ patients and 20 age- and gender-matched HC were enrolled in this study. MEG measurement in resting eyes-open/eyes-closed states for each 10 seconds and to repeat for 8 trials was performed in both groups. The comparisons of mean ERS or ERD values between two groups were also performed using unpaired, two-tailed t-test in Brain Voyager software (BV). A significant positive correlation was found between upper alpha ERS in the left posterior MTG and scores on visual memory subtests of the Wechsler Memory Scale-Revised in SCZ patients (rho=0.57, 0.48; p<0.05). These findings indicate impaired brain oscillatory activity in simple paradigm of resting eyes-open/eyes-closed states in SCZ patients, manifested as decreased upper alpha ERS in the left posterior MTG.

Research Products

• [Journal Article] New possibility of traditional Chinese medicine for the treatments for behavioral and psychiatric symptoms of dementia. (2012)
  • Author(s): Kung FC, Ishii R, Liu HC, Takeda M.
  • Journal Title: Clinical Interventions in Aging Volume: 7 Pages: 393-396
• [Journal Article] Heartbeat evoked potentials: a new possible clinical biomarker for depression based on the somatic marker hypothesis. (2012)
  • Author(s): Ishii R, Canuet L.
  • Journal Title: Clinical Neurophysiology Volume: 123(10) Pages: 1899-1900
• [Journal Article] Publication criteria for evoked magnetic fields of the human brain: a proposal. (2012)
  • Author(s): Ozaki I, Shiraishi H, Kamada K, Kameyama S, Tsuyuguchi N, Yumoto M, Watanabe Y, Hirata M, Ishii R, Iguchi Y, Kimura T, Takino R, Hashimoto I.
  • Journal Title: Clinical Neurophysiology Volume: 123(11) Pages: 2116-2121
• [Journal Article] Influencia del genotipo APOE sobre la actividad cerebral en la enfermedad de Alzheimer. (2012)
  • Author(s): Canuet L, Tellado I, Couceiro V, Fraile C, Fernandez-Novoa L, Ishii R, Takeda M, Cacabelos R.
  • Journal Title: Gen-T The EuroEspes Journal
• [Journal Article] Induced oscillatory responses during the Sternberg's visual memory task in patients with Alzheimer's disease and mild cognitive impairment. (2012)
  • Author(s): Kurimoto R, Ishii R, Canuet L, Ikezawa K, Iwase M, Azechi M, Aoki Y, Ikeda S, Yoshida T, Takahashi H, Nakahachi T, Kazui H, Takeda M.
  • Journal Title: Neuroimage Volume: 59(4) Pages: 4132-4140
• [Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects. (2012)
  • Author(s): Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M.
  • Journal Title: Neurosci Res Volume: 72(2) Pages: 187-193
• [Journal Article] Resting-State Network Disruption and APOE Genotype in Alzheimer's Disease: A lagged Functional Connectivity Study . (2012)
  • Author(s): Canuet L, Tellado I, Couceiro V, Fraile C, Fernandez-Novoa L, Ishii R, Takeda M, Cacabelos R.
  • Journal Title: PLoS One Volume: 7(9) Pages: e46289
• [Journal Article] Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy. (2011)
  • Author(s): Canuet L, Ishii R, Pascual-Marqui RD, Iwase M, Kurimoto R, Aoki Y, Ikeda S, Takahashi H, Nakahachi T, Takeda M.
  • Journal Title: PLoS One. Volume: 6(11) Pages: e27863
• [Journal Article] Psychopathology and working memory-induced activation of the prefrontal cortex in schizophrenia-like psychosis of epilepsy: evidence from Magnetoencephalography. (2011)
  • Author(s): Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Aoki Y, Nakahachi T, Soriano S, Takeda M.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 65
• [Journal Article] Schizophrenia-like psychosis associated with right parietal meningioma. (2011)
  • Author(s): Canuet L, Ikezawa K, Ishii R, Aoki Y , Iwase M, Takeda M.
  • Journal Title: J Neuropsychiatry Clinical Neurosci Volume: 23(3) Pages: E36
• [Journal Article] Frontal shift of posterior alpha activity is correlated with cognitive impairment in early Alzheimer's disease: a magnetoencephalography-beamformer study. (2010)
  • Author(s): Ishii R, Canuet L, Kurimoto R, Ikezawa K, Aoki Y, Azechi M, Takahashi H,Nakahachi T, Iwase M, Kazui H, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 10(3) Pages: 138-43
• [Journal Article] Frontal cortex activation associated with speeded processing of visuospatial working memory revealed by multichannel near-infrared spectroscopy during Advanced Trail Making Test performance. (2010)
  • Author(s): Nakahachi T, Ishii R, Iwase M, Canuet L, Takahashi H, Kurimoto R, Ikezawa K,Azechi M, Kajimoto O, Takeda M.
  • Journal Title: Behav Brain Res Volume: 215(1) Pages: 21-7
• [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population (2010)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, TanakaT,Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry Volume: 11(7) Pages: 852-7
• [Journal Article] Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder:an MEG study. (2010)
  • Author(s): Honaga E, Ishii R, Kurimoto R, Canuet L, Ikezawa K, Takahashi H, Nakahachi T, Iwase M, Mizuta I, Yoshimine T, Takeda M.
  • Journal Title: Neurosci Lett Volume: 478(3) Pages: 141-5
• [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. (2010)
  • Author(s): Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R,Takeda M.
  • Journal Title: Psychophysiology Volume: 47(5) Pages: 831-7
• [Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. (2010)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K,Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
  • Journal Title: Schizophr Res Volume: 116(2-3) Pages: 126-32
• [Journal Article] Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography. (2010)
  • Author(s): Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Nakahachi T, Hashimoto R, Takeda M.
  • Journal Title: Epilepsy Behav Volume: 17(1) Pages: 109-19
• [Journal Article] Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: a near-infrared spectroscopy. (2010)
  • Author(s): Azechi M, Iwase M, Ikezawa K, Takahashi H, Canuet L, Kurimoto R, Nakahachi T, Ishii R, Fukumoto M, Ohi K, Yasuda Y, Kazui H, Hashimoto R, Takeda M.
  • Journal Title: Schizophr Res Volume: 117(1) Pages: 52-60
• [Journal Article] Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography. (2009)
  • Author(s): Ishii R, Canuet L, Herdman A, Gunji A, Iwase M, Takahashi H, Nakahachi T, Hirata M, Robinson SE, Pantev C, Takeda M.
  • Journal Title: Clin Neurophysiol. Volume: 120(3) Pages: 497-504
• [Journal Article] Factors associated with impaired quality of life in younger and older adults with epilepsy . (2009)
  • Author(s): Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Azechi M, Takahashi H, Nakahachi T, Teshima Y, Takeda M.
  • Journal Title: Epilepsy Res Volume: 83(1) Pages: 58-65
• [Journal Article] TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function. (2009)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Kiribayashi M, Iike N, Yoshida T, Azechi M, Ikezawa K, Takahashi H, Morihara T, Ishii R, Tagami S, Iwase M, Okochi M, Kamino K, Kazui H, Tanaka T, Kudo T, Takeda M.
  • Journal Title: Genes Brain Behav Volume: 8(4) Pages: 473-480
• [Journal Article] Neuroimaging studies in patients with Charles Bonnet Syndrome. (2009)
  • Author(s): Kazui H, Ishii R, Yoshida T, Ikezawa K, Takaya M, T okunaga H, Tanaka T, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 9(2) Pages: 77-84
• [Journal Article] Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: A two-channel near-infrared spectroscopy study . (2009)
  • Author(s): Ikezawa K, Iwase M, Ishii R, Azechi M, Canuet L, Ohi K, Yasuda Y, Iike N, Kurimoto R, Takahashi H, Nakahachi T, Sekiyama R, Yoshida T, Kazui H, Hashimoto R, Takeda M.
  • Journal Title: Schizophr Res Volume: 108 Pages: 93-103
• [Journal Article] Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. (2009)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokun
  • Journal Title: Schizophr Res. Volume: 109(1-3) Pages: 80-5
• [Presentation] Relationship of prepulse Inhibition to personality dimensions in Japanese patients with schizophrenia. (2011)
  • Author(s): Hidetoshi Takahashi, Masao Iwase, Yuka Y asuda, Hidenaga Yamamori, Kazutaka Ohi, Motoyuki Fukumoto, Leonides Canuet, Ryouhei Ishii, Hiroaki Kazui, Ryota Hashimoto, Masatoshi Takeda.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague Congress Centre , Prague, Czech Republic
  • Year and Date: 20110530-0602
• [Presentation] Symposium: Electrophysiology, New Insight through Psychophysiological Studyfor Exploring Psychopathology of Schizophrenia Patients: Clinical Application of MEG in Schizophrenia (2011)
  • Author(s): Ishii R
  • Organizer: 2nd Asian Congress on Schizophrenia Research
  • Place of Presentation: The Ritz Carlton Soeul, Soeul, South Korea
  • Year and Date: 2011-02-11
• [Presentation] Cognitive and psychopathological disturbance in schizophrenia-like epilepsy psychosis: a neuroimaging magnetoencephalography study (2011)
  • Author(s): Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Azechi M, Aoki Y, Nakahachi T, Takeda M.
  • Organizer: 2nd Asian Congress on Schizophrenia Research
  • Place of Presentation: The Ritz Carlton Soeul, Soeul, South Korea
  • Year and Date: 2011-02-11
• [Presentation] Mirror neuron system dysfunction in autistic spectrum disorder revealed by spatial filtered magnetic encephalography . (2010)
  • Author(s): E. Honaga, R. Ishii, R. Kurimoto, L. Canuet, K. Ikezawa, H. Takahashi, T. Nakahachi, M. Iwase, S. Ukai, T. Yoshimine, M. Takeda.
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Working memory-induced activation and severity of psychopathology in schizophrenia-like psychosis of epilepsy: evidence from magnetoencephalography (2010)
  • Author(s): L. Canuet, R. Ishii, K. Ikezawa, R. Kurimoto, M. Iwase, H. Takahashi, T. Nakahachi, M. Azechi, Y. Aoki, T. Yoshimine, M. Takeda
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Frontal lobe dysfunction and regional hemodynamic changes in major depression: A near infrared spectroscopy study (2010)
  • Author(s): M. Azechi, M. Iwase, R. Ishii, K. Ikezawa, L. Canuet, R. Kurimoto, H. Takahashi, T. Nakahachi, N. Iike, M. Fukumoto, K. Ohi, H. Yamamori, Y. Yasuda, R. Hashimoto, M. Takeda
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Abnormal cortical oscillatory activity in schizophrenia-like psychosis of epilepsy after resection of meningioma (2010)
  • Author(s): R. Ishii, L. Canuet, K. Ikezawa, R. Kurimoto, M. Iwase, H. Takahashi, T. Nakahachi, M. Azechi, Y. Aoki, T. Yoshimine, M. Takeda
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Two-channel NIRS activation curves of oxyhemoglobin during frontal lobe tasks in schizophrenia (2010)
  • Author(s): M. Iwase, M. Azechi, K. Ikezawa, R. Ishii, H. Takahashi, T. Nakahachi, L. Canuet, R. Kurimoto, H. Kazui, M. Fukumoto, N. Iike, K. Ohi, H. Yamamori, Y. Yasuda, R. Hashimoto, M. Takeda
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Multichannel NIRS revealed frontal cortex activation associated with speeded processing of visuospatial working memory (2010)
  • Author(s): T. Nakahachi, R. Ishii, M. Iwase, L. Canuet, H. Takahashi, R. Kurimoto, K. Ikezawa, M. Azechi, Y. Aoki, O. Kajimoto, M. Takeda
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Assessment of stress states based on EEG activity using multiple regression analysis (2010)
  • Author(s): T. Hayashi, E. Okamoto, S. Ukai, K. Shinosaki, R. Ishii, Y. Mizuno-Matsumoto
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Relationship between personality stability and brain reaction area under the emotional stimuli (2010)
  • Author(s): Y. Mizuno-Matsumoto, T. Hayashi, E. Okamoto, T. Asakawa, R. Ishii, S. Ukai, K. Shinosaki
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 20101028-1101
• [Presentation] Platform presentation: Psychiatry & Neuropsychology. Working memory-induced activation and severity of psychopathology in schizophrenia-like psychosis of epilepsy: evidence from Magnetoencephalography. (2010)
  • Author(s): Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Nakahachi T, Takeda M.
  • Organizer: The 8th Asian & Oceanian Epilepsy Congress
  • Place of Presentation: Melbourne, Austlaria
  • Year and Date: 20101021-24
• [Presentation] Spatially filtered MEG revealed theta and gamma power changes during mental calculation. (2010)
  • Author(s): Ishii R, Canuet L, Ishihara T, Aoki Y, Takahashi H, Nakahachi T, Iwase M, Takeda M
  • Organizer: 第33回日本神経科学会大会 Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 20100902-04
• [Presentation] Two-channel near infrared spectroscopy activation curves of oxyhemoglobin during frontal tasks in schizophrenia (2010)
  • Author(s): IwaseM, Azechi M, Ikezawa K, Ishii R, Takahashi H, Nakahachi T, Canuet L, Aoki Y, Kurimoto R, Kazui K, Fukumoto M, Iike N, Ohi K, Yamamori H,Yasuda Y,Hashimoto R,Takeda M
  • Organizer: 第33回日本神経科学会大会 Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 20100902-04
• [Presentation] Two-channel near infrared spectroscopy (NIRS) activation curves of oxyhemoglobin during frontal lobe tasks in schizophrenia. (2010)
  • Author(s): M. Iwase, M. Azechi, K. Ikezawa, R. Ishii, H. Takahashi, T. Nakahachi, L. Canuet, Y. Aoki, R. Kurimoto, H. Kazui, M. Fukumoto, N. Iike, K. Ohi, H. Yamamori, Y. Yasuda, R. Hashimoto, M. Takeda.
  • Organizer: 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] Depressive state: the strongest predictor of quality of life in elderly patients with epilepsy . (2010)
  • Author(s): Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Azechi M, Takahashi H, Nakahachi T, Teshima Y, Takeda M
  • Organizer: The Hong Kong Psychogeriatric Association Annual Scientific Meeting cum Annual General Meeting
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-11-06
• [Presentation] Frontal shift of posterior alpha activity in early Alzheimer's disease revealed by MEG beamformer analysis (2009)
  • Author(s): Ishii R, Kurimoto R, Ikezawa k, Canuet L, Azechi M, Takahashi H, Nakahachi T, Iwase M, Kazui H, Takeda M
  • Organizer: The International Symposium on Early Detection and Rehabilitation Technology of Dementia
  • Place of Presentation: Okayama
  • Year and Date: 20091211-12
• [Presentation] MEG oscillatory activity during eyes-open/eyes-closed resting state in schizophrenia (2009)
  • Author(s): Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto K, Takamura H, Yasuda Y, Iike N, Takaya M, Kazui H, Hashimoto R, Yoshimine T, Takeda M
  • Organizer: 2nd conference of International Society for the Advancement of Clinical Magnetoencephalography
  • Place of Presentation: Greece
  • Year and Date: 20090903-05
• [Presentation] A case report of Alzheimer disease with Presenilin-1 mutation (Met233Leu) showing a new phenotype (2009)
  • Author(s): Takaya M, Kazui H, Ikezawa K, Kurimoto R, Yamamoto K, Morihara T, Ishii R, Tokunaga H, Takeda M
  • Organizer: Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Messe Wien Exhibition and Congress Center, Vienna, Austria
  • Year and Date: 20090711-16
• [Presentation] Discriminant analysis in schizophrenia and healthy controls using preforntal activation during forntal lobe tasks: a near-infrared spectroscopy study (2009)
  • Author(s): Azechi M, Iwase M, Ikezawa K, Canuet L, Kurimoto R, Takahashi H, Nakahachi T, Ishii R, Fukumoto M, Iike N, Ohi K, Yasuda Y, Kazui H, Hashimoto R, Takeda M.
  • Organizer: 9th World Congress of Biological Psychiatry Paris
  • Place of Presentation: France
  • Year and Date: 20090628-7
• [Presentation] Hypofrontality in schizophrenia detected by the measurement of tissue oxygeneation index using NIRS (2009)
  • Author(s): Iwase M, Azechi M, Ikezawa K, Ishii R, Leonides C, Kurimoto R, Hidetoshi T, Nakahachi T, Kazui H, Fukumoto M, Iike N, Ohi K, Yasuda Y, Hashimoto R, Takeda M
  • Organizer: The 32nd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya
  • Year and Date: 2009-09-18