Neural correlates of plasma acylated ghrelin level in individuals with mood disorders

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591519
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Yamaguchi University
• Principal Investigator: MATSUO Koji 山口大学, 医学部附属病院, 講師 (00292912)
• Co-Investigator(Kenkyū-buntansha): MATSUBARA Toshio 山口大学, 医学部附属病院, 助教 (60526896) ; OTSUKI Koji 山口大学, 大学院・医学系研究科, 助教 (10535256)
• Project Period (FY): 2009 – 2011
• Keywords: うつ病 / グレリン / MRI

Research Abstract

There was no significant difference in plasma acylated ghrelin level between patients with major depressive disorder(MDD) and healthy subjects. In the MDD group, ghrelin levels positively correlated with the severity of reduced appetite. Ghrelin levels negatively correlated with gray matter volume of the ventral tegmental area(VTA) in the total sample. The patients with MDD showed significantly smaller VTA gray matter volume compared to healthy subjects. Our findings suggest that plasma acylated ghrelin is associated with neural abnormalities of the pleasure/ reward system and may be involved in the pathophysiology of MDD.

Research Products

• [Journal Article] Association between prior alcohol use disorders and decreased prefrontal gray matter volumes in bipolar I disorder patients (2011)
  • Author(s): Nery FG, Matsuo K, Nicoletti MA, Monkul ES, Zunta-Soares GB, Hatch JP, Lafer B, Soares JC
  • Journal Title: Neuroscience Letters Volume: 503(2) Pages: 136-140
  • Peer Reviewed
• [Journal Article] State-dependent changes in the expression of DNA methyltransferases in mood disorder patients (2011)
  • Author(s): Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y
  • Journal Title: J Psychiatr Res Volume: 45(10) Pages: 1295-1300
  • Peer Reviewed
• [Journal Article] Altered sirtuin deacetylase gene expression in patients with a mood disorder (2011)
  • Author(s): Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y
  • Journal Title: J Psychiatr Res Volume: 45(8) Pages: 1106-1112
  • Peer Reviewed
• [Journal Article] Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1 (2011)
  • Author(s): Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y
  • Journal Title: Proceedings of the National Academy of Science of the United States of America Volume: 108(4) Pages: 1681-1686
  • Peer Reviewed
• [Journal Article] Epigenetic status of Gdnfin the ventral striatum determines susceptibility and adaptation to daily stressful events (2011)
  • Author(s): Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y
  • Journal Title: Neuron Volume: 69(2) Pages: 359-372
  • Peer Reviewed
• [Journal Article] Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents (2010)
  • Author(s): Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y
  • Journal Title: The Journal of Neuroscience Volume: 30(45) Pages: 15007-15018
  • Peer Reviewed
• [Journal Article] Aberrant REST-mediated transcriptional regulation in major depressive disorder (2010)
  • Author(s): Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y
  • Journal Title: Journal of Psychiatric Research Volume: 44(6) Pages: 378-384
  • Peer Reviewed
• [Journal Article] Altered gene expression of histone deacetylases in mood disorder patients (2010)
  • Author(s): Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y
  • Journal Title: Journal of Psychiatric Research Volume: 44(5) Pages: 263-270
  • Peer Reviewed
• [Journal Article] Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder (2009)
  • Author(s): Matsuo K, Nicoletti MA, Peluso MAM, Hatch JP, Nemoto K, Watanabe Y, Nery FG, Monkul ES, Zunta-Soares GB, Bowden CL, Soares JC
  • Journal Title: Bipolar Disorders Volume: 11(6) Pages: 628-636
  • Peer Reviewed
• [Journal Article] Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder (2009)
  • Author(s): Matsuo K, Walss-Bass C, Nery FG, Nicoletti MA, Hatch JP, Frey BN, Monkul ES, Zunta-Soares GB, Bowden CL, Escamilla MA, Soares JC
  • Journal Title: Neuropsychopharmacology Volume: 34(8) Pages: 1904-1913
  • Peer Reviewed
• [Journal Article] A voxel-based morphometry study of frontal gray matter correlates of impulsivity (2009)
  • Author(s): Matsuo K, Nicoletti M, Nemoto N, Hatch JP, Peluso MAM, Nery FG, Soares JC
  • Journal Title: Human Brain Mapping Volume: 30(4) Pages: 1188-1195
  • Peer Reviewed
• [Presentation] Neural Correlates of Trait Personality in Patients with Mood Disorders (2012)
  • Author(s): Nakano M, Matsuo K, Nakashima M, Egashira K, Matsubara T, Takahashi K, Watanabe Y
  • Organizer: 5th Biennial Conference of the International Society for Bipolar Disorders
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-03-16
• [Presentation] The difference of morphometric abnormalities in unaffected first-degree relatives of bipolar and major depressive disorder (2012)
  • Author(s): Matsubara T, Matsuo K, Nakano M, Nakashima M, Egashira K, Suetsugi M, Matsunaga N, Watanabe Y
  • Organizer: 5th biennial conference of ISBD
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2012-03-16
• [Presentation] NIRS study of brain hemodynamic response during a stop signal task in children (2011)
  • Author(s): Nakashima M, Matsuo K, Hashimoto A, Nakano M, Fujii Y, Egashira K, Matsushige T, Matsubara T, Ichiyama T, Watanabe Y
  • Organizer: 17th Annual Meeting of the Organization on Human Brain Mapping
  • Place of Presentation: Quebec City, Canada
  • Year and Date: 2011-06-19
• [Presentation] Association of Ghrelin Plasma Level and Morphometric Abnormality in Patients with Mood Disorders (2011)
  • Author(s): Matsuo K, Nakano M, Egashira K, Nakashima M, Matsubara T, Watanabe Y
  • Organizer: 17th Annual Meeting of the Organization on Human Brain Mapping
  • Place of Presentation: Quebec City, Canada
  • Year and Date: 2011-06-17
• [Presentation] Neural correlates of motivational behavior with mesolimbic pathway in major depressive disorder (2011)
  • Author(s): Nakano M, Matsuo K, Nakashima M, Egashira K, Matsubara T, Furukawa M, Takahashi K, Nemoto K, Masaki H, Matsunaga N, Watanabe Y
  • Organizer: 17th Annual Meeting of Human Brain Mapping
  • Place of Presentation: Quebec City, Canada
  • Year and Date: 2011-06-17
• [Presentation] 気分障害患者におけるグレリン濃度と脳形態異常との関連 (2011)
  • Author(s): 松尾幸治, 中野雅之, 中島麻美, 古林亜由美, 原久美子, 藤井優子, 橋本亜希子, 江頭一輝, 内田周作, 松原敏郎, 渡邉義文
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京ホテルグランパシフィックLE DAIBA
  • Year and Date: 2011-05-22
• [Presentation] Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4 (2010)
  • Author(s): Otsuki K, Uchida S, Yamagata H, Watanabe Y
  • Organizer: Neuroscience 2010, SfN' s 40th annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-13
• [Presentation] Morphometric correlate of decision making under ambiguity and risk (2010)
  • Author(s): Nakano M, Matsuo K, Nakashima M, Egashira K, Matsubara T, Furukawa M, Takahashi K, Nemoto K, Masaki H, Matsunaga N, Watanabe Y
  • Organizer: 16th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-09
• [Presentation] Front-limbic morphometric correlates of genetic risk for bipolar disorder (2010)
  • Author(s): Matsuo K, Kopecek M, Nicoletti MA, Hatch JP, Watanabe Y, Nery FG, Zunta-Soares GB, Soares JC
  • Organizer: 16th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-07
• [Presentation] Fronto-limbic morphometric abnormalities signal genetic risk for bipolar disorder (2009)
  • Author(s): Matsuo K, Kopecec M, Nicoletti MA, Hatch JP, Watanabe Y, Nery FG, Zunta-Soares G, Soares JC
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-21
• [Presentation] Antidepressants increase transcriptional activity of GDNF gene via the histone modification (2009)
  • Author(s): Otsuki K, Uchida S, Watanabe Y
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-20