Plasma adipocytokines, and BDNF levels in patients with eating disorders : Relationship with short-term outcome

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka City University
• Principal Investigator: NAGATA Toshihiko 大阪市立大学, 大学院・医学研究科, 准教授 (80237528)
• Co-Investigator(Kenkyū-buntansha): YAMADA Hisashi 大阪市立大学, 大学院・医学研究科, 病院講師 (20464646) ; FUKUHARA Hidehiro 大阪市立大学, 大学院・医学研究科, 病院講師 (10464645)
• Project Period (FY): 2009 – 2011
• Keywords: Brain-derived neurotrophic factor / adipocytokines / bulimia nervosa / anorexia nervosa

Research Abstract

Plasma resisitin levels in patients with bulimia nervosa were significantly lower than in controls, and the level was negatively correlated with the frequency of binge eating, depressive and anxiety scores. Plasma BDNF levels in patients with bulimia nervosa were significantly lower than in controls, but significantly icreased after short-term inpatient treatment.

Research Products

• [Journal Article] Recovery of low plasma BDNF over the course of treatment among patients with bulimia nervosa (2012)
  • Author(s): Yamada H, Yoshimura C, Nakajima T, Nagata T
  • Journal Title: Psychiatry Res Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] No association of Brain-Derived Neurotrophic Factor Val66Met Polymorphism with Anorexia Nervosa in Japanese (2012)
  • Author(s): Ando, T., Ishikawa T., Hotta M., Naruo T., Okabe, K., Nakahara, T., Takii, M., Kawai, K., Mera, T., Nakamoto, C., Takei, M., Yamaguchi, C., Nagata, T., Okamoto, Y., Ookuma, K., Koide, M., Yamanaka, T., Murata, S., Tamura, N., Kiriike, N., Ichimaru, Y., Komaki, G.
  • Journal Title: Am J Med Genet Part B Neuropsychiatric Genetics Volume: 159B Pages: 48-52
• [Journal Article] A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders : a retrospective survival analysis (2010)
  • Author(s): Ando, T., Komaki, G., Nishimura, H., Naruo, T., Okabe, K., Kawai, K., Takii, M., Oka, T., Kodama, N., Nakamoto, C., Ishikawa, T., Suzuki-Hotta, M., Minatozaki, K., Yamaguchi, C., Nishizono-Maher, A., Kono, M., Kajiwara, S., Suematsu, H., Tomita, Y., Ebana, S., Okamoto, Y., Nagata, K., Nakai, Y., Koide, M., Kobayashi, N., Kurokawa, N., Nagata, T., Kiriike, N., Takenaka, Y., Nagamine, K., Ookuma, K. & Murata, S.
  • Journal Title: Psychiatr Genet Volume: 20 Pages: 153-159
• [Journal Article] 摂食障害患者の変化への段階と早期治療脱落 (2010)
  • Author(s): 山田恒, 永田利彦, 吉村知穂, 中島豪紀, 切池信夫
  • Journal Title: 精神医学 Volume: 52(9) Pages: 853-861
• [Journal Article] ひきこもる摂食障害を就労支援へつなげることのできた2症例 (2010)
  • Author(s): 永田利彦, 村上澄子, 熊谷幸市, 山田恒, 吉村知穂, 中島豪紀, 切池信夫
  • Journal Title: 精神医学 Volume: 52 Pages: 17-24
• [Journal Article] 就労支援事業が就労につながった全般性社交不安障害(回避性パーソナリティ障害)の2症例 (2009)
  • Author(s): 永田利彦, 村上澄子, 熊谷幸市, 山田恒, 吉村知穂, 中島豪紀, 切池信夫
  • Journal Title: 精神医学 Volume: 51 Pages: 1157-1163
• [Presentation] Comparison of comorbidity between female social anxiety disorder patients with and without eating disorders (2010)
  • Author(s): Nagata, T. et al
  • Organizer: Eating Disorders Research Society 16th Annual Meeting
  • Place of Presentation: Cambridge, Massachusetts, USA
  • Year and Date: 20101007-09
• [Book] 摂食障害治療ガイドライン (2012)
  • Author(s): 永田利彦
  • Total Pages: 15-18, 179-182, 186-190, 260-262
  • Publisher: 医学出版
• [Book] 摂食障害 (2011)
  • Author(s): 永田利彦
  • Total Pages: 873-874
  • Publisher: 医学書院
• [Book] 摂食障害の入院治療-より現実的な着地点を目指して (2010)
  • Author(s): 永田利彦
  • Total Pages: 29-38
  • Publisher: 中山書店
• [Book] 不安障害(パニック障害、社交不安障害)、摂食障害、パーソナリティ障害への対応 (2009)
  • Author(s): 永田利彦
  • Total Pages: 114-124
  • Publisher: 中山書店
• [Book] 弁証法的行動療法 (2009)
  • Author(s): 永田利彦
  • Total Pages: 144-147
  • Publisher: 診断と治療社