Longitudinal study of the relationship among psychiatric symptoms, social functioning and brain basis in individuals with an at-risk mental state(ARMS).

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591533
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Toho University
• Principal Investigator: MIZUNO Masafumi 東邦大学, 医学部, 教授 (80245589)
• Co-Investigator(Kenkyū-buntansha): MIZUMURA Sunao 東邦大学, 医学部, 准教授 (90287748) ; MORITA Keiko 東邦大学, 医学部, 助教 (20449242) ; NEMOTO Takahiro 東邦大学, 医学部, 准教授 (20296693) ; KATAGIRI Naoyuki 東邦大学, 医学部, 助教 (70459759)
• Co-Investigator(Renkei-kenkyūsha): HORI Masaaki 順天堂大学, 医学部, 准教授 (40334867)
• Project Period (FY): 2009 – 2011
• Keywords: 脳・神経 / 精神医学

Research Abstract

To investigate the biological changes in the brain of individuals with an at-risk mental state, we compared the differences between ARMS subjects and healthy control subjects using MRI. The main findings were:
Reduction of the white matter integrity in corpus callosum and cingulum of ARMS subjects compared to healthy control subjects.
Volume reduction of the entorhinal cortex after a year of follow-up among ARMS subjects who developed psychosis compared to subjects those who did not.

Research Products

• [Journal Article] Cerebral blood flow changes in very-late-onset schizophrenia-like psychosis with catatonia before and after successful treatment : a case report (2011)
  • Author(s): Naohisa Tsujino, Takahiro Nemoto, Taiju Yamaguchi, Naoyuki Katagiri, Nao Tohgi, Ryu Ikeda ; Nobuyuki Shiraga, Sunao Mizumura, Masafumi Mizuno
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 600-613
  • Peer Reviewed
• [Journal Article] Lack of association between psychosis-like experiences and seeking help from professionals : A case-controlled study (2011)
  • Author(s): Hiroyuki Kobayashi, Takahiro Nemoto, Masaaki Murakami, Haruo Kashima, Masafumi Mizuno
  • Journal Title: Schizophrenia Research Volume: 132 Pages: 208-212
  • Peer Reviewed
• [Journal Article] Successful aging in individuals with schizophrenia dwelling in the community : A study on attitudes toward aging and preparing behavior for old age (2011)
  • Author(s): Niimura H, Nemoto T, Yamazawa R, Kobayashi H, Ryu Y, Sakuma K, Kashima H, Mizuno M
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 459-467
  • Peer Reviewed
• [Presentation] Fractional anisotropy reductions in ciugulum bundle and corpus callosum in at risk mental state (2012)
  • Author(s): Naoyuki Katagiri, Masaaki Hori, Takahiro Nemoto, Naohisa Tsujino, Keiko Morita, Junichi Saito, Keigo Shimoji, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
  • Organizer: 3rd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 20120414-18
• [Book] 精神病の早期診断実践ハンドブック (2011)
  • Author(s): 水野雅文監訳、小林啓之訳
  • Total Pages: 312
  • Publisher: 医学書院
• [Book] 精神科臨床倫理第4版 (2011)
  • Author(s): 水野雅文、藤井千代、村上雅昭、菅原道哉監訳
  • Total Pages: 721
  • Publisher: 星和書店