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2011 Fiscal Year Final Research Report

Analysis of Dicc-M KO mice to reveal the pathogenesis of schizophrenia

Research Project

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Project/Area Number 21591535
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

OHNISHI Tetsuo  独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (80373281)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Takeo  独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
Co-Investigator(Renkei-kenkyūsha) ITOKAWA Masanari  (財)東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 (40332324)
ARAI Makoto  (財)東京都医学研究機構, 東京都精神医学総合研究所, 研究員 (80356253)
Project Period (FY) 2009 – 2011
Keywords統合失調症 / ノックアウトマウス / 行動実験 / DISC1 / 転写因子
Research Abstract

In this study, we have focused on the schizophrenia-relevant gene DISC1, which is disrupted by a chromosomal break seen in a Japanese schizophrenic patient. Because the function of this gene remains totally unknown, we first set out to examine the phenotype of Disc-M KO mice. The KO mice exhibited multiple deficits relevant to schizophrenia : hyperacticity in the drug-naive mice, hypersensitivity to NMDA antagonist and DA agonist. Interestingly, cued fear conditioning was totally damaged by disruption of the Disc-M gene. These data may reflect that disruption of the gene by the chromosomal break this gene is really pathogenic at least in the proband.

  • Research Products

    (5 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice2011

    • Author(s)
      Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, Iwayama Y, Toyota T, Maekawa M, Watanabe K, Detera-Wadleigh SD, Wakana S, Yoshikawa T
    • Journal Title

      PLoS One

      Volume: 6(12) Pages: e29499

    • Peer Reviewed
  • [Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1(SHMT1) in mice and in schizophrenia2010

    • Author(s)
      Maekawa M, Ohnishi T, Hashimoto K, Watanabe A, Iwayama Y, Ohba H, Hattori E, Yamada K, Yoshikawa T
    • Journal Title

      J Neurochem

      Volume: 115(6) Pages: 1374-85

    • Peer Reviewed
  • [Journal Article] Enhanced carbonyl stress in a subpopulation of schizophrenia2010

    • Author(s)
      Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M
    • Journal Title

      Arch Gen Psychiatry

      Volume: 67(6) Pages: 589-97

    • Peer Reviewed
  • [Presentation] Mice deficient in a gene encoding a transcriptional regulator exhibit multiple behavioral deficits reminiscent of schizophrenia2011

    • Author(s)
      Ohnishi T, Watanabe A, M. Arai, Itokawa M, Yoshikawa T, et al
    • Organizer
      66th Annual Meeting, Society for Biological Psychiatry
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-05-14
  • [Book] 第三章脳神経系:精神疾患2011

    • Author(s)
      大西哲生、吉川武男
    • Total Pages
      76-83
    • Publisher
      中山書店

URL: 

Published: 2013-07-31  

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