2011 Fiscal Year Final Research Report
Evaluation of improved therapeutic effect of radioisotope therapy combining targeted inhibition of amino acid transporter.
| Project/Area Number |
21591544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
HIGUCHI Tetsuya 群馬大学, 大学院・医学系研究科, 准教授 (60323367)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Keigo 京都医療科学大学, 学長 (10115800)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アミノ酸輸送担体(LAT1) / 神経内分泌腫瘍 / F-18標識αメチルタイロシン / ポジトロンCT / RI内用療法 |
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| Research Abstract |
Correlation of 18^F-AMT uptake and cellular growth activity evaluated by Ki-67 labeling index was assessed in patients with head and neck cancer. As a result, significant correlation of both indexes was confirmed. As for 131^I-MIBG therapy, the early therapeutic response by the measurement of serum catecholamine 1 week after injection of 131^I-MIBG was assessed and serum catecholamine is proved to be significantly related with better response. Furthermore, diagnostic utility of FDG-PET/CT comparing with 123I-MIBG scintigraphy and X-ray CT in the evaluation of therapeutic effect of 131^I-MIBG was assessed and it is confirmed that FDG-PET/CT is useful in the evaluation of therapeutic response of 131^I-MIBG in malignant pheochromocytoma.
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